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Vol. 36 No. 3 (2024): Vol 36 Issue 3, 2024

Copyright (c) 2024 Aravinda Kumar Madugula, K. Jagadeesh, D.B.N. Suresh Varma, K. Ganesh Kadiyala, Srinivasa Rao Pedada, Rama Swamy Guttula, U. Nagababu, Gururaja Rangaiah

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A New Series of Indole and Azaindole Derivatives with Oxo-dihydropyridines: Synthesis, Characterization and Cytotoxicity Studies against Breast Malignant Cell Lines

https://doi.org/10.14233/ajchem.2024.30317
Aravinda Kumar Madugula
Centre for Research and Development, PRIST University, Thanjavur-613403, India
https://orcid.org/0009-0003-8775-6344
K. Jagadeesh
Department of Chemistry, Shri Vishnu Engineering College for Women, Bhimavaram-534202, India
https://orcid.org/0000-0002-3805-4931
D.B.N. Suresh Varma
Department of Chemistry, Shri Vishnu Engineering College for Women, Bhimavaram-534202, India
https://orcid.org/0000-0002-9921-9461
K. Ganesh Kadiyala
Department of Chemistry, Shri Vishnu Engineering College for Women, Bhimavaram-534202, India
https://orcid.org/0000-0001-7357-0504
Srinivasa Rao Pedada
Centre for Research and Development, PRIST University, Thanjavur-613403, India
https://orcid.org/0009-0007-2241-8730
Rama Swamy Guttula
Department of Chemistry, Vishnu Institute of Technology, Bhimavaram-534202, India
https://orcid.org/0000-0001-7321-6660
U. Nagababu
Department of Engineering Chemistry, S.R.K.R. Engineering College, Chinna Amiram-534204, India
https://orcid.org/0000-0002-3328-9280
Gururaja Rangaiah
Centre for Research and Development, PRIST University, Thanjavur-613403, India
https://orcid.org/0000-0002-2797-0870

Corresponding Author(s) : K. Jagadeesh

kadali.jc@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 3 (2024): Vol 36 Issue 3, 2024

Abstract

In this investigation, a novel series of indole and azaindole comprising oxo-dihydropyridine derivatives was synthesized. From their spectral (1H NMR and FTIR) as well as elemental (MS) investigations, the structures of all the synthesized 12 oxo-dihydropyridine derivatives were determined. Cytotoxicity of synthesized twelve compound was evaluated against MDA-MB-231 malignant breast cells had been assessed. Compound 1,6-diamino-4-(1H-indol-3-yl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile showed more percent of inhibition of growth and four more derivatives showed moderate percent of inhibition of growth counter to MDA-MB-231 malignant breast cells. The derivative 1,6-diamino-4-(1H-indol-3-yl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile showed the highest effectiveness when assessing the IC50 value against the malignant breast cell line MDA-MB-231. Each of the compounds synthesized has a druggable character and meets Lipinski’s criteria of five.

Keywords

Dihydropyridine derivatives MDA-MB-231 cell line Breast cancer Lipinski’s criteria Inhibition of growth
Madugula, A. K., Jagadeesh, K., Varma, D. S., Kadiyala, K. G., Pedada, S. R., Guttula, R. S., … Rangaiah, G. (2024). A New Series of Indole and Azaindole Derivatives with Oxo-dihydropyridines: Synthesis, Characterization and Cytotoxicity Studies against Breast Malignant Cell Lines. Asian Journal of Chemistry, 36(3), 669–676. https://doi.org/10.14233/ajchem.2024.30317
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