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Vol. 36 No. 6 (2024): Vol 36 Issue 6, 2024

Copyright (c) 2024 Rijulal G, A. Krishnakumar, K. Anoop Krishnan, M.K. Geetha Nambiar

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Physico-Chemical and Biological Properties of Lanthanide(III) Complexes with Schiff Base of 4-Formyl Antipyrine

https://doi.org/10.14233/ajchem.2024.31337
G. Rijulal
Department of Chemistry, Government College, Chittur-678104, India
https://orcid.org/0000-0001-9722-7786
A. Krishnakumar
National Centre of Earth Science Studies, Akkulam-695011, India
https://orcid.org/0000-0001-9142-4797
K. Anoop Krishnan
National Centre of Earth Science Studies, Akkulam-695011, India
https://orcid.org/0000-0003-4435-8410
M.K. Geetha Nambiar
Department of Chemistry, Government College, Malappuram-676539, India
https://orcid.org/0009-0005-8658-2674

Corresponding Author(s) : G. Rijulal

rijulalg@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 6 (2024): Vol 36 Issue 6, 2024

Abstract

The synthesis of two novel Schiff base ligands viz. 4-[N-(3-methoxyphenylmethanamine)formyl]-2,3-dimethyl-1-phenyl-3-pyazolin-5-one (3MPMAFA) and 4-[N-(4-methoxyphenylmethanamine)formyl]-2,3-dimethyl-1-phenyl-3-pyazolin-5-one (4MPMAFA) was undertaken with the aim of synthesizing a total of 14 novel lanthanide(III) complexes. The synthesized ligands and its lanthanide(III) complexes were characterized by various analytical techniques such as elemental analysis, molecular mass, molar conductance, magnetic moment, FTIR, UV-visible and 13C NMR spectral data. According to the physico-chemical data, both Schiff bases (3MPMAFA and 4MPMAFA) appear as a neutral bidentate ligand coordinated through azomethine nitrogen and carbonyl oxygen atom. With a tentative monocapped octahedral geometry and coordination number seven, all the complexes have the same general formula, [ML2(NO3)3] (where M = La(III), Pr(III), Nd(III), Sm(III), Gd(III), Dy(III), Yb(III) and L = 3MPMAFA/4MPMAFA). The ligands and their Ln(III) complexes were evaluated for their biological activities revealing that all the lanthanide(III) complexes exhibited superior antibacterial capabilities compared to the ligands.

Keywords

Lanthanide(III) complexes Schiff base Antipyrine-4-carboxaldehyde Biological studies
Rijulal, G., Krishnakumar, A., Krishnan, K. A., & Nambiar, M. G. (2024). Physico-Chemical and Biological Properties of Lanthanide(III) Complexes with Schiff Base of 4-Formyl Antipyrine. Asian Journal of Chemistry, 36(6), 1245–1250. https://doi.org/10.14233/ajchem.2024.31337
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