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Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

Copyright (c) 2024 Gopi Chandravadivelu, MAGHARLA DASARATHA DHANARAJU, KONATHAM PRANUSHA, THIYAGARAJAN DEEPAN, AR MAGESH, DHANARAJU KAVITHA

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Design, Synthesis, Characterization and Antitubercular Activity of Novel Benzimidazole Mannich Base Derivatives

Anti-tubercular activity of novel Benzimidazole Mannich base derivatives
https://doi.org/10.14233/ajchem.2024.31314
Chandravadivelu Gopi
Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajamahendravaram-533296, India
https://orcid.org/0000-0001-7382-5474
Magharla Dasaratha Dhanaraju
Research Lab, GIET School of Pharmacy, Rajamahendravaram-533296, India
https://orcid.org/0000-0003-4876-7051
Konatham Pranusha
Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajamahendravaram-533296, India
https://orcid.org/0009-0000-8156-8754
Thiyagarajan Deepan
Department of Pharmaceutical Analysis, GIET School of Pharmacy, Rajamahendravaram-533296, India
https://orcid.org/0000-0003-4062-3993
AR Magesh
Department of Pharmaceutical Analysis, GIET School of Pharmacy, Rajamahendravaram-533296, India
https://orcid.org/0000-0003-4062-3993
Dhanaraju Kavitha
Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajamahendravaram-533296, India
https://orcid.org/0000-0003-3745-7939

Corresponding Author(s) : Chandravadivelu Gopi

gopi@giet.ac.in

Asian Journal of Chemistry, Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

Abstract

In present work, the newly synthesized benzimidazole Mannich base derivatives were design, synthesized and evaluated the in silico and in vitro antitubercular activity. These compounds were synthesized by condensation reaction between 1-(1H-benzo[d]imidazol-1-yl)ethanone and aliphatic/aromatic amines. The synthesized compound structures were identified by FTIR, 13C NMR, 1H NMR and mass spectroscopies. The results indicated that these derivatives have significant antitubercular activity against Mycobacterium tuberculosis (M.tb) cell wall enzyme enoyl acyl carrier protein reductase (InhA), EthR regulatory protein in H73Rv strain. The results found in the in vitro study are firmly similar to the in silico study. Among the synthesized compounds, 3d and 3e exhibited the highest activity due to the connection of the electron-donating group to the Mannich base. Therefore, these compounds deserve the development of new antitubercular agents.

Keywords

Benzimidazole Mannich base Aliphatic/aromatic amines Antitubercular activity
Gopi, C., Dhanaraju, M. D., Pranusha, K., Deepan, T., Magesh, A., & Kavitha, D. (2024). Design, Synthesis, Characterization and Antitubercular Activity of Novel Benzimidazole Mannich Base Derivatives: Anti-tubercular activity of novel Benzimidazole Mannich base derivatives. Asian Journal of Chemistry, 36(4), 969–973. https://doi.org/10.14233/ajchem.2024.31314
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