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Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

Copyright (c) 2024 Jayadevappa HP, Arpitha M K, vidyashree K M, sonakshi H S

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A Comparative Kinetic Study of Uncatalyzed and Ce(IV) Catalyzed Cetrizine Dihydrochloride Oxidation in Aqueous Acid Medium by Chloramine-T

https://doi.org/10.14233/ajchem.2024.31305
M.K. Arpitha
Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore-570006, India
https://orcid.org/0009-0007-4983-1701
K.M. Vidyashree
Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore-570006, India
H.S. Sonakshi
Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore-570006, India
H.P. Jayadevappa
Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore-570006, India
https://orcid.org/0000-0003-4925-7782

Corresponding Author(s) : H.P. Jayadevappa

hpjayadevappa@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

Abstract

A kinetic study of uncatalyzed and Ce(IV) catalyzed cetrizine dihydrochloride oxidation was carried out in aqueous acid medium using chloramine-T. Both uncatalyzed and catalyzed reactions follows first order kinetics with respect to [CAT] and fractional order kinetics with respect to [substrate]. The reaction follows first order dependence on [CeIV] catalyst. The uncatalyzed reaction shows inverse fractional order for [H+] and [Cl–] whereas catalyzed reaction follows fractional order. The effect of ionic strength is negligible in both cases. The dielectric constant has negative effect on uncatalyzed reaction and positive effect on catalyzed reaction. To compute the thermodynamic parameters the kinetic runs were studied at different temperatures (293-313 K). The stoichiometry of the reaction was studied and the products of oxidation were analyzed. The rate law was also derived by the proposed mechanism.

Keywords

Chloramine-T Cetrizine dihydrochloride Rate law Oxidation Mechanism Cerium(IV) catalyst
Arpitha, M., Vidyashree, K., Sonakshi, H., & Jayadevappa, H. (2024). A Comparative Kinetic Study of Uncatalyzed and Ce(IV) Catalyzed Cetrizine Dihydrochloride Oxidation in Aqueous Acid Medium by Chloramine-T. Asian Journal of Chemistry, 36(4), 955–962. https://doi.org/10.14233/ajchem.2024.31305
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