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Vol. 36 No. 5 (2024): Vol 36 Issue 5, 2024

Copyright (c) 2024 Mir Mohammad Masood

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1,2,3-Triazole Containing Hybrids as Potential Pharmacological Agents: A Review

https://doi.org/10.14233/ajchem.2024.31274
Mir Mohammad Masood
Department of Chemistry, Government Degree College, Doda-182202, India
https://orcid.org/0000-0002-3788-7261
Arshid Iqbal
Department of Botany, Government College for Women, M.A. Road, Srinagar-190001, India
https://orcid.org/0009-0003-2861-3255

Corresponding Author(s) : Mir Mohammad Masood

mirmmasood@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 5 (2024): Vol 36 Issue 5, 2024

Abstract

1,2,3-Triazoles constitute a versatile class of nitrogen containing five-membered heterocycles, exhibiting wide range of pharmacological properties which include antibacterial, antifungal, anticancer, antimalarial, antidiabetic, anti-inflammatory, antihypertensive and antioxidant, among various others. Medicinal chemists have been interested in this aromatic ring as a framework since the inception of click chemistry as considered as the building block of contemporary organic chemistry. Extensive research into this framework’s linker characteristic has led to the synthesis and evaluation of numerous 1,2,3-triazole hybrids bearing a wide range of heterocyclic moieties as potential leads for various biological targets. This molecular hybridization has also added advantage of the improved pharmacological activity overcoming the problem of multiple drug resistance and reduced toxicity. This review summarizes the pharmacological activities of various 1,2,3-triazole containing hybrids and conjugates, covering articles published in past decade (2013 till date) and will be of great assistance to medicinal chemistry researchers in providing a useful direction for the future drug discovery.

Keywords

1,2,3-Triazoles Pharmacological activities Molecular hybridization Drug discovery
Masood, M. M., & Iqbal, A. (2024). 1,2,3-Triazole Containing Hybrids as Potential Pharmacological Agents: A Review. Asian Journal of Chemistry, 36(5), 983–1008. https://doi.org/10.14233/ajchem.2024.31274
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Author Biography

Arshid Iqbal, Department of Botany, Government College for Women, M.A. Road, Srinagar-190001, India

Assistant Professor

Department of Botany

Government College for Women M. A. Road Srinagar, Jammu and Kashmir 190001, India.

Statistic
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