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Vol. 36 No. 5 (2024): Vol 36 Issue 5, 2024

Copyright (c) 2024 Dr. Anuruddha Chabukswar, Dr. Prajakta Adsule, Dr. Swati Jagdale, Dishank Purandare, Kunal Raut, Yash Kale

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Molecular Modeling and Cytotoxicity Study of New 3-Phenyl Coumarin Derivatives against in vitro Cell Lines

https://doi.org/10.14233/ajchem.2024.31269
Anuruddha Chabukswar
Department of Pharmaceutical Sciences, School of Health Sciences & Technology, Dr. Vishwanath Karad MIT World Peace University, Pune-411038, India
https://orcid.org/0000-0002-2868-6652
Prajakta V. Adsule
Department of Pharmaceutical Sciences, School of Health Sciences & Technology, Dr. Vishwanath Karad MIT World Peace University, Pune-411038, India
https://orcid.org/0000-0001-8009-2731
Swati Jagdale
Department of Pharmaceutical Sciences, School of Health Sciences & Technology, Dr. Vishwanath Karad MIT World Peace University, Pune-411038, India
https://orcid.org/0000-0003-2914-7420
Dishank V. Purandare
Department of Pharmaceutical Sciences, School of Health Sciences & Technology, Dr. Vishwanath Karad MIT World Peace University, Pune-411038, India
https://orcid.org/0009-0001-2822-700X
Kunal Raut
Department of Pharmaceutical Sciences, School of Health Sciences & Technology, Dr. Vishwanath Karad MIT World Peace University, Pune-411038, India
https://orcid.org/0000-0002-3072-4953
Yash Kale
Department of Pharmaceutical Sciences, School of Health Sciences & Technology, Dr. Vishwanath Karad MIT World Peace University, Pune-411038, India
https://orcid.org/0009-0009-6906-2860

Corresponding Author(s) : Prajakta V. Adsule

prajakta.adsule81@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 5 (2024): Vol 36 Issue 5, 2024

Abstract

In pursuit of more effective cancer treatments, researchers embarked on a study to enhance the coumarin derivative’s therapeutic potential. These compounds, known for their anticancer properties, have faced challenges such as increased toxicity and drug resistance. The research aimed to design, synthesize and assess new 3-phenyl coumarin derivatives specifically for breast and lung cancer treatment. Utilizing 3-oxoacyl-reductase (1T8I), a series of compounds were synthesized from aromatic aldehydes and phenylacetic acid. Among the synthesized 11 compounds that were examined, compounds C01, C04, C05 and C08 had significant cytotoxic effects on both MCF-7 and MRC-5 cell lines. Particularly, compound C08, featuring ethoxy and nitrate substitution, exhibited remarkable potential against both cancer cell lines, emphasizing its promise for further exploration in cancer therapy.

Keywords

Cancer Cytotoxicity Coumarin MRC-5 cell lines MCF-7 cell lines
Chabukswar, A., Adsule, P. V., Jagdale, S., Purandare, D. V., Raut, K., & Kale, Y. (2024). Synthesis, Molecular Modeling and Cytotoxicity Study of New 3-Phenyl Coumarin Derivatives against in vitro Cell Lines. Asian Journal of Chemistry, 36(5), 1061–1066. https://doi.org/10.14233/ajchem.2024.31269
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