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Vol. 36 No. 5 (2024): Vol 36 Issue 5, 2024

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A Facile Solution Phase Synthesis of Peptide Assemblies as Functional Moiety for Antimicrobial and Anticancer Peptides

https://doi.org/10.14233/ajchem.2024.31218
L. Edwin Paul
Department of Organic and Bioorganic Chemistry, CSIR-Central Leather Research Institute (CLRI), Chennai-600020, India Department of Chemistry, Presidency College, Chennai-600005, India
https://orcid.org/0009-0008-2339-2285
M. Shanmugavel
Department of Microbiology, CSIR-Central Leather Research Institute, Chennai-600020, India
https://orcid.org/0000-0001-5526-3404
P. Ganesan
Department of Biochemistry and Biotechnology, CSIR-Central Leather Research Institute, Chennai-600020, India
https://orcid.org/0000-0001-5223-419X
T.S. Kiruthika
Department of Chemistry, Presidency College, Chennai-600005, India
https://orcid.org/0009-0006-5177-9052
V. Jaisankar
Department of Chemistry, Presidency College, Chennai-600005, India
https://orcid.org/0000-0003-0894-4703

Corresponding Author(s) : V. Jaisankar

vjaisankar@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 5 (2024): Vol 36 Issue 5, 2024

Abstract

In recent years, human being are affected by various types of cancer and are highly microbial infected due to changes in environmental conditions and hence, the recovery from this cause of disease using peptide-based drugs as a function of both activities like antimicrobial peptides (AMPs) and anticancer peptides (ACPs). Herein, we report the solution phase peptide synthesis using α-amino acids such as alanine, phenylalanine and lysine. The structural parameters of the polypeptides were investigated by circular dichroism, FT-IR, MALDI-TOF ESI-mass, NMR, etc. Water-soluble hydrophilic-based synthesized polypeptides possess various biological applications throughout, especially antibacterial and anticancer activities–short reaction process, less cost of chemicals, minimum glassware and no hazardous chemicals involved. Multiple species have innate immune systems that contain antimicrobial peptides (AMPs). Most of them have been proved to possess dual action, both as antibacterial and anticancer peptides, making them most promising alternative to conventional compounds used today to treat these infections. Present approach offers unique opportunities for developing highly potent and focused antibacterial and anticancer peptide-based drugs.

Keywords

Antimicrobial peptides Anticancer peptides Solution phase peptide synthesis Amino acids
Paul, L. E., Shanmugavel, M., Ganesan, P., Kiruthika, T., & Jaisankar, V. (2024). A Facile Solution Phase Synthesis of Peptide Assemblies as Functional Moiety for Antimicrobial and Anticancer Peptides. Asian Journal of Chemistry, 36(5), 1035–1039. https://doi.org/10.14233/ajchem.2024.31218
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