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Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

Copyright (c) 2024 Dr Deepak Wadhwa, Jyoti, Suman Devi, Dr Vikram Kumar

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Design, Development and Molecular Docking Studies of C-2 Sulfenylated Benzofurans: Potential Interleukin 1-β Antagonist

https://doi.org/10.14233/ajchem.2024.31210
Jyoti
Department of Chemistry, Chaudhary Bansi Lal University, Bhiwani-127021, India
https://orcid.org/0009-0003-2854-3074
Suman Devi
Department of Chemistry, Chaudhary Bansi Lal University, Bhiwani-127021, India
https://orcid.org/0009-0006-5902-5941
Vikram Kumar
Department of Chemistry, I.B. College, Panipat-132103, India
https://orcid.org/0000-0002-7315-4532
Deepak Wadhwa
Department of Chemistry, Chaudhary Bansi Lal University, Bhiwani-127021, India
https://orcid.org/0000-0002-3948-0414

Corresponding Author(s) : Deepak Wadhwa

deepak_chem08@cblu.ac.in

Asian Journal of Chemistry, Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

Abstract

An environmental friendly methodology for C-2 sulfenylation of benzofurans through dehydrogenative cross-coupling has been developed. Sulfenylation at second position is carried out using commercially available thiols in presence of molecular iodine and DMSO. The reaction accommodates wide spectrum of electronically diverse substituents on thiophenol ring. This process offers diverse advantages, including greener reaction conditions, moderate to good percentage yields, easy workup, no additional metal catalysts requirement and gram scale synthesis. Molecular docking studies is also conducted to substantiate interleukin 1-β antagonist nature of the designed compounds.

Keywords

Benzofuran Sulfenylation Thiophenol Iodine DMSO
Jyoti, Devi, S., Kumar, V., & Wadhwa, D. (2024). Design, Development and Molecular Docking Studies of C-2 Sulfenylated Benzofurans: Potential Interleukin 1-β Antagonist. Asian Journal of Chemistry, 36(4), 879–884. https://doi.org/10.14233/ajchem.2024.31210
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Author Biography

Vikram Kumar, Department of Chemistry, I.B. College, Panipat-132103, India

Assistant Professor at the Department of Chemistry, I.B. College Panipat

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