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Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

Copyright (c) 2024 Najma Bajracharya, Sunita Shrestha, Gan Bajracharya

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Magnesium Powder-Catalyzed, Highly Efficient, Solvent-Free Synthesis of Amides through N-Acetylation of Amines and their Antibacterial Activity

https://doi.org/10.14233/ajchem.2024.31196
Najma Bajracharya
Laboratory of Catalysis and Frontier Molecules, Faculty of Science, Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur, Nepal
https://orcid.org/0009-0005-0882-0083
Sunita Shrestha
Laboratory of Catalysis and Frontier Molecules, Faculty of Science, Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur, Nepal Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Ghantaghar, Kathmandu, Nepal
https://orcid.org/0009-0005-5373-183X
Gan B. Bajracharya
Laboratory of Catalysis and Frontier Molecules, Faculty of Science, Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur, Nepal
https://orcid.org/0000-0002-3061-6557

Corresponding Author(s) : Gan B. Bajracharya

ganbajracharya@yahoo.com

Asian Journal of Chemistry, Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

Abstract

Magnesium powder was found to be an efficient catalyst for the acetylation of amines (1) with Ac2O affording corresponding amides (2) in excellent yields (> 99%). This green synthetic protocol has utilized 2.5 mol% of magnesium powder and a stoichiometric amount of Ac2O (1.2 equiv.). Amides 2a-k were synthesized within a short reaction time (2-3 min) at an ambient temperature under solvent free condition. The products were screened against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Staphylococcus epidermidis bacterial strains. N-(2-Hydroxyphenyl)acetamide (2f) was found most active against Gram-positive S. aureus and S. epidermidis indicating its efficacy in treating skin diseases.

Keywords

Acylation Antibacterial assay Green chemistry Skin disease Solvent-free Organic synthesis
Bajracharya, N., Shrestha, S., & Bajracharya, G. B. (2024). Magnesium Powder-Catalyzed, Highly Efficient, Solvent-Free Synthesis of Amides through N-Acetylation of Amines and their Antibacterial Activity. Asian Journal of Chemistry, 36(4), 859–864. https://doi.org/10.14233/ajchem.2024.31196
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