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Vol. 36 No. 1 (2024): Vol 36 Issue 1, 2024

Copyright (c) 2023 P. Kaviyarasi , S. Manivannan

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Anticancer and Antioxidant Activities of Biologically Active Newly Synthesized α-Amino Acid-Dithiocarbamate Complexes of Some Bivalent Metals

https://doi.org/10.14233/ajchem.2024.28241
P. Kaviyarasi
PG & Research Department of Chemistry, Dr. Ambedkar Govt. Arts College, Chennai-600039, India
https://orcid.org/0009-0005-3765-271X
S. Manivannan
PG & Research Department of Chemistry, Dr. Ambedkar Govt. Arts College, Chennai-600039, India
https://orcid.org/0000-0002-4254-2954

Corresponding Author(s) : P. Kaviyarasi

kaviyarasi1983@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 1 (2024): Vol 36 Issue 1, 2024

Abstract

The present study focuses on the synthesis and characterization of L-proline dithiocarbamate and its L-prodtc metal(II) (M = Ni2+, Cu2+ and Se2+) complexes. The ligand was synthesized in the presence of an alkali through the reaction of one mole of carbon  disulphide and L-proline in ethanol under ice cold condition. The solubility of this ligand in the media is attributed to its high  hygroscopic character and therefore, its metal(II) complexes were synthesized using a freshly prepared ligand. The characterization of  the metal(II) complexes were carried out by molar conductance, magnetic susceptibility, elemental analysis, TGA/DTA, mass, IR,  Raman, UV-Visible, 1H and 13C NMR spectroscopic studies. The biological activity of all the metal(II) complexes has been examined  using an inhibition method for bacteria and pathogenic fungus, which will assess their possible antibacterial, antioxidant, anticancer  activities and anti-inflammatory. It has been observed that Se(L-Prodtc)2 exhibits anticancer activity against breast cancer cells (MCF7)  and also observed that antioxidant activity of Se(L-Prodtc)2 is more as compared to standard BHT, whereas Cu(L-Prodtc)2 complex  shows appreciable anti-inflammatory activity. 

Keywords

Dithiocarbamate Metal(II) complexes L-Proline Raman Antioxidant Antimicrobial agent
Kaviyarasi , P., & Manivannan , S. (2023). Anticancer and Antioxidant Activities of Biologically Active Newly Synthesized α-Amino Acid-Dithiocarbamate Complexes of Some Bivalent Metals. Asian Journal of Chemistry, 36(1), 37–43. https://doi.org/10.14233/ajchem.2024.28241
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