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Vol. 36 No. 3 (2024): Vol 36 Issue 3, 2024

Copyright (c) 2024 Ranajit Sutradhar

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Thiazole Schiff Base Analogs

https://doi.org/10.14233/ajchem.2024.31077
Muhammad Zoadur Rahman
Department of Chemistry, Chittagong University of Engineering & Technology, Chattogram 4349, Bangladesh
https://orcid.org/0009-0005-4498-4114
Md. Din Islam
Department of Chemistry, Chittagong University of Engineering & Technology, Chattogram 4349, Bangladesh
https://orcid.org/0000-0003-4652-8081
Md. Aminul Haque
Department of Chemistry, Jagannath University, Dhaka 1100, Bangladesh
https://orcid.org/0000-0001-5514-1597
Mohammad Mostafizur Rahman
Department of Chemistry, Jagannath University, Dhaka 1100, Bangladesh
https://orcid.org/0000-0002-0434-3401
Emdad Hossain
Wazed Miah Science Research Center, Jahangirnagar University, Savar, Dhaka, Bangladesh
Ranajit Kumar Sutradhar
Department of Chemistry, Chittagong University of Engineering & Technology, Chattogram 4349, Bangladesh
https://orcid.org/0000-0002-6020-0528

Corresponding Author(s) : Ranajit Kumar Sutradhar

rksutradhar2002@yahoo.com

Asian Journal of Chemistry, Vol. 36 No. 3 (2024): Vol 36 Issue 3, 2024

Abstract

In this work, potentially safe few Schiff base compounds containing a thiazole moiety were synthesized and characterized. Three thiazole derivatives (2a-c) were successfully synthesized through a two-step reaction involving substituted benzaldehyde, thiosemicarbazide and 1,3-dichloroacetone. The elucidation of the synthesized compounds was accomplished by using spectral studies. Antimicrobial activities demonstrated that some compounds exhibited moderate effectiveness against microbes, compared to the standard antibiotic’s ceftriaxone and amphotericin B, using the disc diffusion technique. In the DPPH free radical scavenging assay, all compounds displayed promising antioxidant effectiveness. Moreover, the molecular docking studies showed that thiazole Schiff base analogs effectively bind to potential receptor binding sites.

Keywords

Schiff base Thiazole Antimicrobial activity Antioxidant activity Molecular docking
Rahman, M. Z., Islam, M. D., Haque, M. A., Rahman, M. M., Hossain, E., & Sutradhar, R. K. (2024). Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Thiazole Schiff Base Analogs. Asian Journal of Chemistry, 36(3), 649–654. https://doi.org/10.14233/ajchem.2024.31077
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