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Vol. 30 No. 9 (2018): Vol 30 Issue 9

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Synthesis of Novel Series of Quinolino[3,2-f][1,2,4]triazolo[3,4-b][1,3,4]-thiadiazepines Derivatives Incorporated with 3-[5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl] Moiety as Potent Antimicrobial Agent

https://doi.org/10.14233/ajchem.2018.21483
M. Idrees
Department of Chemistry, Government Institute of Science, Nagpur-440 001, India
S. Kola
Department of Chemistry, Government Science College, Gadchiroli-442 605, India
N.J. Siddiqui
Department of Chemistry, Government Institute of Science, Nagpur-440 001, India

Corresponding Author(s) : M. Idrees

idreesshaikh.2009@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 9 (2018): Vol 30 Issue 9

Abstract

A novel series of quinolino[3,2-f][1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine derivatives (7a-i) incorporated with 3-[5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl] moiety were synthesized through one-pot cyclo-condensation reaction of 5-[5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl]-4-amino-4H-1,2,4-triazole-3-thiol (4) with 2-chloroquinoline-3-carbaldehyde derivatives (6a-i) in presence of potassium carbonate in DMF. The characterization of newly synthesized compounds 3-[5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl]-substituted quinolino[3,2-f][1,2,4]triazolo[3,4-b][1,3,4]thiadiazepines (7a-i) was established by elemental analysis and spectral studies such as FT-IR, 1H NMR, 13C NMR and Mass spectra. All the synthesized compounds were screened in vitro for their antimicrobial activity against pathogenic microorganism including Gram-positive bacterial strains, S. aureus and Gram-negative bacteria strains E. coli, P. vulgaris and S. typhi at different concentration. The result of bioassay when compared with chloramphenicol as standard drug indicated good to moderate activity against these microbial strains.

Keywords

1,3,4-Thiadiazepine 1,2,4-Triazole Quinoline Benzofuran Pyrazole
Idrees, M., Kola, S., & Siddiqui, N. (2018). Synthesis of Novel Series of Quinolino[3,2-f][1,2,4]triazolo[3,4-b][1,3,4]-thiadiazepines Derivatives Incorporated with 3-[5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl] Moiety as Potent Antimicrobial Agent. Asian Journal of Chemistry, 30(9), 2129–2133. https://doi.org/10.14233/ajchem.2018.21483
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