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Vol. 30 No. 9 (2018): Vol 30 Issue 9

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Bis(4,5-dihydropyrazole) Derivatives: Synthesis, Characterization and Antimicrobial-Antioxidant Evaluations

https://doi.org/10.14233/ajchem.2018.21451
Mohamad Yusuf
Department of Chemistry, Punjabi University, Patiala-147 002, India
Saloni Thakur
Department of Chemistry, Punjabi University, Patiala-147 002, India

Corresponding Author(s) : Mohamad Yusuf

yusuf_sah04@yahoo.co.in

Asian Journal of Chemistry, Vol. 30 No. 9 (2018): Vol 30 Issue 9

Abstract

In the present work, five new bispyrazolines 3(a-e) have been prepared from the cyclization reaction of bischalcones 2(a-e) with phenyl hydrazine under alcoholic medium. The bischalcones 2(a-e) were synthesized by using the alkylation of chalcone 1 with appropriate alkylating agents. The structures of the newly prepared products were confirmed by IR, 1H and 13C NMR and ESI-MS. The final products were screened for their antimicrobial and antioxidant properties. The ortho-xylene linked bispyrazoline showed significant antimicrobial action while the bischalcones proved themselves significant antioxidant.

Keywords

Bischalcone Phenylhydrazine Bispyrazolines Biological activities
Yusuf, M., & Thakur, S. (2018). Bis(4,5-dihydropyrazole) Derivatives: Synthesis, Characterization and Antimicrobial-Antioxidant Evaluations. Asian Journal of Chemistry, 30(9), 2097–2102. https://doi.org/10.14233/ajchem.2018.21451
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