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Vol. 30 No. 8 (2018): Vol 30 Issue 8

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Study on Poly(vinyl alcohol) Coated Superparamagnetic Nanoparticles via RAFT Polymerization Methodology for Drug Delivery System Loaded Anti-Inflammatory

https://doi.org/10.14233/ajchem.2018.21245
Trinh Duy Nguyen1
1NTT Institute of High Technology, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, District 4, Ho Chi Minh City, Vietnam 2Hochiminh University of Natural Resources and Environment, 236B Le Van Sy, Ward 1, Tan Binh District, Ho Chi Minh City, Vietnam 3Department of Chemical Engineering, HCMC University of Technology, VNU-HCM, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam *Corresponding author: Fax: +84 28 39404759; Tel: +84 96 9294297; E-mail: blgiang@ntt.edu.vn
Sang Thanh Vo1
1NTT Institute of High Technology, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, District 4, Ho Chi Minh City, Vietnam 2Hochiminh University of Natural Resources and Environment, 236B Le Van Sy, Ward 1, Tan Binh District, Ho Chi Minh City, Vietnam 3Department of Chemical Engineering, HCMC University of Technology, VNU-HCM, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam *Corresponding author: Fax: +84 28 39404759; Tel: +84 96 9294297; E-mail: blgiang@ntt.edu.vn
Van Thi Thanh Ho2
1NTT Institute of High Technology, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, District 4, Ho Chi Minh City, Vietnam 2Hochiminh University of Natural Resources and Environment, 236B Le Van Sy, Ward 1, Tan Binh District, Ho Chi Minh City, Vietnam 3Department of Chemical Engineering, HCMC University of Technology, VNU-HCM, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam *Corresponding author: Fax: +84 28 39404759; Tel: +84 96 9294297; E-mail: blgiang@ntt.edu.vn
Xuan Tien Le3
1NTT Institute of High Technology, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, District 4, Ho Chi Minh City, Vietnam 2Hochiminh University of Natural Resources and Environment, 236B Le Van Sy, Ward 1, Tan Binh District, Ho Chi Minh City, Vietnam 3Department of Chemical Engineering, HCMC University of Technology, VNU-HCM, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam *Corresponding author: Fax: +84 28 39404759; Tel: +84 96 9294297; E-mail: blgiang@ntt.edu.vn
Long Giang Bach1
1NTT Institute of High Technology, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, District 4, Ho Chi Minh City, Vietnam 2Hochiminh University of Natural Resources and Environment, 236B Le Van Sy, Ward 1, Tan Binh District, Ho Chi Minh City, Vietnam 3Department of Chemical Engineering, HCMC University of Technology, VNU-HCM, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam *Corresponding author: Fax: +84 28 39404759; Tel: +84 96 9294297; E-mail: blgiang@ntt.edu.vn

Asian Journal of Chemistry, Vol. 30 No. 8 (2018): Vol 30 Issue 8

Abstract

In this study, Fe3O4 magnetic nanoparticles grafted with poly(vinyl alcohol) (PVA-g-MNPs) were successfully fabricated via reversible addition-fragmentation chain transfer (RAFT) polymerization with two main steps: (a) chain transfer agent for RAFT, S-benzyl S′-trimethoxysilylpropyltrithiocarbonate was immobilized onto the surface of MNPs, and (b) poly(vinyl alcohol) was grafted onto the MNPs surface through RAFT polymerization. The results demonstrated the growth of PVA chains onto the surface of MNPs via directly hydrolyzed of PVA-g-MNPs. The covalent functionalization, structure, morphology and magnetic property of PVA-g-MNPs nanocomposites were characterized using XPS, FT-IR, EDX, TGA and SQUID analyses. In addition, drug loading/release potentialities of PVA-g-MNPs was investigated using ibuprofen as a model drug and evaluated using UV-visible spectroscopic technique. Evaluation of nano-medicine based on as-synthesized PVA-g-MNPs (in vitro) suggested that this material can be an attractive candidate for chemotherapeutic efficacy against cancer cell lines.

Keywords

Poly(vinyl alcohol) Superparamagnetic nanoparticles Drug delivery system Cytotoxicity.
Duy Nguyen1, T., Thanh Vo1, S., Thi Thanh Ho2, V., Tien Le3, X., & Giang Bach1, L. (2018). Study on Poly(vinyl alcohol) Coated Superparamagnetic Nanoparticles via RAFT Polymerization Methodology for Drug Delivery System Loaded Anti-Inflammatory. Asian Journal of Chemistry, 30(8), 1711–1716. https://doi.org/10.14233/ajchem.2018.21245
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