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Vol. 30 No. 8 (2018): Vol 30 Issue 8

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Green Synthesis, Cyclization and Biological Study of Novel Series of 1,8-Naphthyridines Using Friedlander Condensation

https://doi.org/10.14233/ajchem.2018.21432
R. N
1R&D Centre, Bharathiar University, Coimbatore-641 046, India 2Department of Chemistry, The Kavery Engineering College, Mecheri, Salem-636 453, India 3PG & Research Department of Chemistry, Islamiah College, Vaniyambadi-635 752, India *Corresponding author: E-mail: nandhikumar@gmail.com
K. Subramani1
1R&D Centre, Bharathiar University, Coimbatore-641 046, India 2Department of Chemistry, The Kavery Engineering College, Mecheri, Salem-636 453, India 3PG & Research Department of Chemistry, Islamiah College, Vaniyambadi-635 752, India *Corresponding author: E-mail: nandhikumar@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 8 (2018): Vol 30 Issue 8

Abstract

A novel and green synthesis of 1,8-naphthyridines like 2,2,2-trifluoro-1-(2-methyl-1,8-naphthyridin- 3-yl)ethanone, 2,2,2-trifluoro-1-(2-phenyl-1,8-naphthyridin-3-yl)ethanone, 2-trifluoro-1-(2-phenyl-1,8-naphthyridin-3-yl)ethanone, 1-(2-(4-chlorophenyl)-1,8-naphthyridine-3-yl)-2,2,2-trifluoroethanone, 2,2,2-trifluoro-1-(2-(furan-2-yl)-1,8-naphthyridin-3-yl)ethanone and 2,2,2-trifluoro-1-(2-(thiophen-2-yl)-1,8-naphthyridin-3-yl)ethanone from ecofriendly and inexpensive NaH catalyzed Friedlander condensation of 2-aminonicotinaldehyde (1) through carbonyl complexes containing a-methylene moiety (2) has been achieved in eco-friendly by microwave irradiation. Elemental analysis, TLC, IR, 1H NMR, 13C NMR and GC-Mass spectroscopy were analyzed the compounds character. The final compounds were tested antimicrobial culture study. In the antibacterial and antifungal study the compounds 3d and 3e shows very good activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus and 3b, 3c, 3d, 3e and 3f shows good action against Penicillium species, Candida albicans and Aspergillus niger, compare to 3a. In this article, a very simple and low-cost method is described for the production of a novel sequence of 1,8-naphthyridines complex and provide very good microbial activity.

Keywords

2-Aminonicotinaldehyde Microwave Antibacterial activity Antifungal activity.
N, R., & Subramani1, K. (2018). Green Synthesis, Cyclization and Biological Study of Novel Series of 1,8-Naphthyridines Using Friedlander Condensation. Asian Journal of Chemistry, 30(8), 1909–1914. https://doi.org/10.14233/ajchem.2018.21432
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