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Vol. 30 No. 8 (2018): Vol 30 Issue 8

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Microwave Assisted Synthesis, Characterization, Molecular Docking and Antiinflammatory Activity of p-Methoxy Cinnamic Acid Derivatives

https://doi.org/10.14233/ajchem.2018.21302
M. Soujanya*
Department of Pharmaceutical Chemistry, Gokula Krishna College of Pharmacy, Sullurpeta-524 121, India *Corresponding author: E-mail: soujipharma@gmail.com
A.V.L.S. Ramakrishna
Department of Pharmaceutical Chemistry, Gokula Krishna College of Pharmacy, Sullurpeta-524 121, India *Corresponding author: E-mail: soujipharma@gmail.com
Ch. Pushya Ragini
Department of Pharmaceutical Chemistry, Gokula Krishna College of Pharmacy, Sullurpeta-524 121, India *Corresponding author: E-mail: soujipharma@gmail.com
V. Jyothsna
Department of Pharmaceutical Chemistry, Gokula Krishna College of Pharmacy, Sullurpeta-524 121, India *Corresponding author: E-mail: soujipharma@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 8 (2018): Vol 30 Issue 8

Abstract

All the title compounds benzamido-(4-methoxy)-N2-(arylidene)cinnamic acid hydrazide (1-13) were synthesized by the microwave irradiation of a-benzamido-(4-methoxy)cinnamalhydrazide (II) with different aromatic/hetero aromatic aldehydes and characterized by IR, 1H and 13C NMR, Mass spectral and elemental analysis. Furthermore, all the new derivatives were screened for antiinflammatory activity by Carrageenan induced rat paw edema method. Compound 3, 6 and 12 exhibited highest activities, which are further supported by molecular docking studies showed -9.7, -8.1 and -8.6 as dock scores respectively. All the title compounds obey the Lipinski rule of five and devoid from toxicity assessed by Molinspiration and Osiris online predictors respectively.

Keywords

Cinnamamic acid derivatives Microwave technique Antiinflammatory activity Molecular docking Lipinski rule of five
Soujanya*, M., Ramakrishna, A., Pushya Ragini, C., & Jyothsna, V. (2018). Microwave Assisted Synthesis, Characterization, Molecular Docking and Antiinflammatory Activity of p-Methoxy Cinnamic Acid Derivatives. Asian Journal of Chemistry, 30(8), 1781–1786. https://doi.org/10.14233/ajchem.2018.21302
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