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Vol. 30 No. 8 (2018): Vol 30 Issue 8

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Effect of Ferric Nanoparticles on Monoaminoxidase and Acetylcholinesterase in Healthy Human Sera

https://doi.org/10.14233/ajchem.2018.21284
Fadhela M. Huseein
Chemistry Department, College of Science, Al-Mustansiryah University, Baghdad, Iraq *Corresponding author: Email: wessalmetaab@yahoo.com; wessalmetaab@uomustansiriyah.edu.iq
Shaemaa H. Abdulsada*
Chemistry Department, College of Science, Al-Mustansiryah University, Baghdad, Iraq *Corresponding author: Email: wessalmetaab@yahoo.com; wessalmetaab@uomustansiriyah.edu.iq
Wessal M. Khamis
Chemistry Department, College of Science, Al-Mustansiryah University, Baghdad, Iraq *Corresponding author: Email: wessalmetaab@yahoo.com; wessalmetaab@uomustansiriyah.edu.iq
Salma Abdulredha
Chemistry Department, College of Science, Al-Mustansiryah University, Baghdad, Iraq *Corresponding author: Email: wessalmetaab@yahoo.com; wessalmetaab@uomustansiriyah.edu.iq
Bayader F. Abbas
Chemistry Department, College of Science, Al-Mustansiryah University, Baghdad, Iraq *Corresponding author: Email: wessalmetaab@yahoo.com; wessalmetaab@uomustansiriyah.edu.iq

Asian Journal of Chemistry, Vol. 30 No. 8 (2018): Vol 30 Issue 8

Abstract

In this study the Fe2O3 nanoparticles were prepared by sol-gel method. The size distributions of the metals nanoparticles were examined by FTIR spectrophotometer, atomic force microscopy and X-ray diffraction which illustrated that the nanoparticles were with hexagonal shape having averaged diameter of 54 nm derived from oleic acid. At the other side the nanoparticles prepared for carboxylic acid were irregular and unsystematic distributed with a maximum value of 0.38 and 2.9 nm exhibits morphology with a root-mean square (RMS) roughness of 0.077 and 0.494 nm for carboxylic acid. The effect of Fe2O3 nanoparticles were studied on the activities of monoaminoxidase (MAO) and acetylcholinesterase (AChE) in sera. Ferric nanoparticles demonstrated inhibitor effect on MAO and AChE and these effect increase with increasing the concentration of nanoparticles. The values of Vmax and Km were achieved and calculated for these nanoparticales.

Keywords

Ferric Nanoparticales Monoaminoxidase enzyme Acetylcholinesterase enzyme.
M. Huseein, F., H. Abdulsada*, S., M. Khamis, W., Abdulredha, S., & F. Abbas, B. (2018). Effect of Ferric Nanoparticles on Monoaminoxidase and Acetylcholinesterase in Healthy Human Sera. Asian Journal of Chemistry, 30(8), 1747–1750. https://doi.org/10.14233/ajchem.2018.21284
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