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Vol. 30 No. 7 (2018): Vol 30 Issue 7

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Synthesis, Characterization and Biological Activities of Some Metal Complexes Derived from Azo Dye Ligand 2-[2'-(5-Methyl thiazolyl)azo]-5-dimethylamino Benzoic Acid

https://doi.org/10.14233/ajchem.2018.21222
Khalid J. Al-Adilee
Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniya 1753, Iraq
Sudad A. Jaber
Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniya 1753, Iraq

Corresponding Author(s) : Khalid J. Al-Adilee

khalidke_1962@yahoo.com; Khalid.Jawad@qu.edu.iq

Asian Journal of Chemistry, Vol. 30 No. 7 (2018): Vol 30 Issue 7

Abstract

In this paper we report the synthesis and identification of Ni(II), Cu(II) and Zn(II) complexes with new thiazole based azo dye 2-[2’-(5-methyl thiazolyl)azo]-5-dimethyl amino benzoic acid (5-MeTAMB) by the diazotization of 2-amino-5-methyl thiazole and coupling with 3-dimethyl amino benzoic acid in alkaline alcoholic solution. The structures of the azo dye ligand and its metal complexes were confirmed by various analytical techniques like by elemental analysis (C.H.N.S), UV-visible, FT-IR spectroscopic, mass spectroscopic, 1H NMR spectroscopic, SEM, XRD data and thermal studies (TGA & DSC). The magnetic moment value of metal complexes [ML2] M = Ni(II) and Cu(II) occurs in the range of high spin octahedral environment of azo ligand while Zn(II) complex show diamagnetic properties and octahedral structure. The analytical and spectral techniques show that the ligand coordinates as tridentate (N,N,O) donor molecule. The antibacterial and antifungal activity of the thiazolylazo ligand and its metal complexes have shown activity towards both bacterial and fungal strains. The biological activity was also conducted by cells cytotoxicity and viability of the ligand and Cu(II)-complex was screened for in vitro, antitumor activity against human breast cancer using MTT assay. The results shows that this type of compounds plays an important role in the rate of inhibition of the growth of cells of cancerous and natural lines and indicate undoubtedly the possibility of using them as antitumor drugs against breast cancer.

Keywords

Synthesis Thiazolylazo dye Metal complexes Spectral studies Biological activity Anticancerous
Al-Adilee, K. J., & Jaber, S. A. (2018). Synthesis, Characterization and Biological Activities of Some Metal Complexes Derived from Azo Dye Ligand 2-[2’-(5-Methyl thiazolyl)azo]-5-dimethylamino Benzoic Acid. Asian Journal of Chemistry, 30(7), 1537–1545. https://doi.org/10.14233/ajchem.2018.21222
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