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Vol. 30 No. 6 (2018): Vol 30 Issue 6

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Synthesis and Antitumor Evaluation of Novel 5-Bromo Indole-Aryl Keto Hydrazide-Hydrazone Analogues

https://doi.org/10.14233/ajchem.2018.21114%20
Durgesh Rudavath
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522 510, India
Reddymasu Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada-533 003, India
Srinivasa Rao Pinapati
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522 510, India
Rudraraju Ramesh Raju
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522 510, India

Corresponding Author(s) : Rudraraju Ramesh Raju

rrraju1@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 6 (2018): Vol 30 Issue 6

Abstract

A wide variety of indole, substituted benzaldehyde linked keto hydrazide-hydrazone analogues were designed, synthesized and evaluated for their cytotoxicity against eight human cancer cell lines HeLa, A549, MCF-7, K562, HEK293, HT29, SF295 and HL60. All these synthesized compounds showed potent antitumor activities on the above eight human cancer cell lines. Among them, 6a and 6h compounds exhibited potent antitumor activity on HL 60 and A549 cancer cell lines with IC50 value of 3.913 and 4.838 μM than the standard drug cisplatin with IC50 values of 27 and 36 μM, respectively.

Keywords

5-Bromo indole Keto hydrazide-hydrazones Lung cancer Bone marrow cancer MTT assay
Rudavath, D., Sreenivasulu, R., Pinapati, S. R., & Raju, R. R. (2018). Synthesis and Antitumor Evaluation of Novel 5-Bromo Indole-Aryl Keto Hydrazide-Hydrazone Analogues. Asian Journal of Chemistry, 30(6), 1201–1204. https://doi.org/10.14233/ajchem.2018.21114
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