Issue

Vol. 30 No. 6 (2018): Vol 30 Issue 6

Copyright (c) 2018 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Spectral Characterization and in vitro Antidiabetic Properties of Oxovanadium(IV) Complexes with 2-{(E)-Pyridin-4-yl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine

https://doi.org/10.14233/ajchem.2018.21249
Babbu Lal Patel
Department of Chemistry, S.G.S. Government P. G. College, Sidhi-486 661, India
Yogendra Pratap Singh
Department of Chemistry, A.P.S. University, Rewa-486 003, India
R.N. Patel
Department of Chemistry, A.P.S. University, Rewa-486 003, India
P.K. Singh
Department of Chemistry, S.G.S. Government P. G. College, Sidhi-486 661, India

Corresponding Author(s) : Babbu Lal Patel

babbulalpatel@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 6 (2018): Vol 30 Issue 6

Abstract

A series of oxovanadium(IV) complexes [VO(phen)(L)](NO3)2 (1), [VO(dimphen)(L)](NO3)2 (2), [VO(bpy)(L)](NO3)2 (3) and [VO(bpybenImH)(L)](NO3)2 (4) with mixed ligands, a tridentate N,N,N-donor Schiff base ligand [viz., 2-{(E)-pyridin-4-yl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine] (L) and a bidentate N,N ligand [viz., 1,10-phenanthroline (phen), 4,7-dimethyl-1,10-phenanthroline (dimphen), 2,2′-bipyridyl (bpy) and 2-(2-pyridyl)benimidazole (bipybenImH)], have been synthesized and characterized by elemental analysis, UV-visible spectroscopy, Fourier transform IR spectroscopy, EPR spectroscopy, cyclic voltammetric and differential pulse voltammetric techniques. The oxidation state of V(IV) with d1 configuration was confirmed by EPR spectroscopy. The complexes were also tested for in vitro antidiabetic activity. Moderate α-glucosidase inhibitions are shown by these complexes. This suggested that the complexes may be promising candidates as antidiabetic agents.

Keywords

Oxovanadium(IV) complexes UV-visible Electrochemistry Anti-diabetic activity
Patel, B. L., Singh, Y. P., Patel, R., & Singh, P. (2018). Synthesis, Spectral Characterization and in vitro Antidiabetic Properties of Oxovanadium(IV) Complexes with 2-{(E)-Pyridin-4-yl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine. Asian Journal of Chemistry, 30(6), 1359–1363. https://doi.org/10.14233/ajchem.2018.21249
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. D.C. Crans, J.J. Smee, E. Gaidamauskas and L. Yang, Chem. Rev., 104, 849 (2004); https://doi.org/10.1021/cr020607t.
  2. M.R. Maurya, A. Kumar, M. Ebel and D. Rehder, Inorg. Chem., 45, 5924 (2006); https://doi.org/10.1021/ic0604922.
  3. Y. Shechter, L. Goldwaser, M. Mironchik, M. Fridkin and D. Gefel, Coord. Chem. Rev., 237, 3 (2003); https://doi.org/10.1016/S0010-8545(02)00302-8.
  4. G.Y. Yeh, D.M. Eisenberg, T.J. Kaptchuk and R.S. Phillips, Diabetes Care, 26, 1277 (2003); https://doi.org/10.2337/diacare.26.4.1277.
  5. B. Song, N. Aebischer and C. Orvig, Inorg. Chem., 41, 1357 (2002); https://doi.org/10.1021/ic0111684.
  6. D. Rehder, Biometals, 5, 3 (1992); https://doi.org/10.1007/BF01079691.
  7. U. Schollowock, J. Richter, D.J.J. Farnell and R.F. Bishop, Quantum Magnetism, Springer-Verlage, New York (2004).
  8. V.G. Yuen, P. Caravan, L. Gelmini, N. Glover, J.H. McNeill, I.A. Setyawati, Y. Zhou and C. Orvig, J. Inorg. Biochem., 68, 109 (1997); https://doi.org/10.1016/S0162-0134(97)00082-2.
  9. H. Sakurai, K. Fujii, H. Watanabe and H. Tamura, Biochem. Biophys. Res. Commun., 214, 1095 (1995); https://doi.org/10.1006/bbrc.1995.2398.
  10. J. Leiter, J.L. Hartwell, J.S. Kahler, I. Kline and M.J. Shear, J. Natl. Cancer Inst., 14, 365 (1953); https://doi.org/10.1093/jnci/14.2.365.
  11. C. Krishnamurty, L.A. Byran and D.H. Petering, Cancer Res., 40, 4092 (1980).
  12. R.N. Patel and Y.P. Singh, J. Mol. Struct., 1153, 162 (2018); https://doi.org/10.1016/j.molstruc.2017.10.010.
  13. R.N. Patel and Y.P. Singh, Asian J. Chem., 29, 2327 (2017); https://doi.org/10.14233/ajchem.2017.20921.
  14. R.N. Patel, Y.P. Singh, Y. Singh, R.J. Butcher and J.P. Jasinski, Polyhedron, 133, 102 (2017); https://doi.org/10.1016/j.poly.2017.05.028.
  15. Y.P. Singh, R.N. Patel, Y. Singh, D. Choquesillo-Lazarte and R.J. Butcher, Dalton Trans., 46, 2803 (2017); https://doi.org/10.1039/C6DT04661D.
  16. S. Mishra, K.B. Pandeya, A.K. Tiwari, A.Z. Ali and T. Saradamani, J. Indian Chem. Soc., 88, 1195 (2011).
  17. W.J. Geary, Coord. Chem. Rev., 7, 81 (1971); https://doi.org/10.1016/S0010-8545(00)80009-0.
  18. S.K. Dutta, E.R.T. Tiekink and M. Chaudhury, Polyhedron, 16, 1863 (1997); https://doi.org/10.1016/S0277-5387(96)00491-3.
  19. M. Akbar Ali, A.H. Mirza, C.W. Voo, A.L. Tan and P.V. Bernhardt, Polyhedron, 22, 3433 (2003); https://doi.org/10.1016/j.poly.2003.08.004.
  20. A.P. Rebolledo, M. Vieites, D. Gambino, O.E. Piro, E.E. Castellano, C.L. Zani, E.M. Souza-Fagundes, L.R. Teixeira, A.A. Batista and H. Beraldo, J. Inorg. Biochem., 99, 698 (2005); https://doi.org/10.1016/j.jinorgbio.2004.11.022.
  21. Y.P. Singh, R.N. Patel, Y. Singh, R.J. Butcher, P.K. Vishakarma and R.K.B. Singh, Polyhedron, 122, 1 (2017); https://doi.org/10.1016/j.poly.2016.11.013.
  22. S.B. Etcheverry, E.G. Ferrer, L. Naso, J. Rivadeneira, V. Salinas and P.A.M. Williams, J. Biol. Inorg. Chem., 13, 435 (2008); https://doi.org/10.1007/s00775-007-0332-9.
  23. P.A.M. Williams, S.B. Etcheverry and E.J. Baran, Carbohydr. Res., 329, 41 (2000); https://doi.org/10.1016/S0008-6215(00)00171-3.
  24. S.B. Etcheverry, D.A. Barrio, P.A.M. Williams and E.J. Baran, Biol. Trace Elem. Res., 84, 227 (2001); https://doi.org/10.1385/BTER:84:1-3:227.
  25. A. Sreedhara, C.P. Rao and B.J. Rao, Carbohydr. Res., 289, 39 (1996); https://doi.org/10.1016/0008-6215(96)00100-0.
  26. R.N. Patel, K. Maurya, Y.P. Singh, Y. Singh, S. Rather, A. Kamal and I.P. Tripathi, J. Indian Chem. Soc., 94, 347 (2017).
  27. S. Mishra, K.B. Pandeya, A.K. Tiwari, A.Z. Ali, T. Saradamani, S.B. Agawane and K. Madhusudana, Int. J. Nutr. Metab., 4, 11 (2012).
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 1 Download : 0