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Vol. 30 No. 5 (2018): Vol 30 Issue 5, 2018

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Synthesis, Characterization and Antidiabetic Activity of Some Water Soluble Zn(II) Complexes with (E)-N-(Thiophen-2-ylmethylene)anilines

https://doi.org/10.14233/ajchem.2018.21216
Debabrata Paria
Department of Chemistry, National Institute of Technology Agartala, Jirania-799 046, India
Sajal Kundu
Department of Chemistry, National Institute of Technology Agartala, Jirania-799 046, India
Khaidem Kennedy Singh
Department of Forestry, North Eastern Regional Institute of Science and Technology, Nirjuli-791 109, India
S. Sureshkumar Singh
Department of Forestry, North Eastern Regional Institute of Science and Technology, Nirjuli-791 109, India
Keisham Surjit Singh
Department of Chemistry, National Institute of Technology Agartala, Jirania-799 046, India

Corresponding Author(s) : Sajal Kundu

kundu12@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 5 (2018): Vol 30 Issue 5, 2018

Abstract

Synthesis and spectroscopic characterization of five water soluble zinc(II) complexes of (E)-N-(thiophen-2-ylmethylene)anilines (L1-3) with the general formula [ZnX2L1-3; X = Cl–, NO3–; (1-5)] are reported. The complexes were characterized by elemental analysis, UV-visible, fluorescence, IR and 1H NMR spectroscopy. Efforts for getting single crystal suitable for X-ray crystal structure could not be achieved. However, from spectroscopic data, the complexes are proposed to adopt four coordinated tetrahedral and six coordinated octahedral geometry. All the complexes were obtained in moderate to good yields and these compounds behave as non-electrolytes in acetonitrile solution. UV-visible and fluorescence spectral study of complexes 1-5 indicate (intra-ligand) ligand to ligand charge transfer transition. The complexes were screened for their antidiabetic activity against α-glucosidase enzyme and compared with standard drug acarbose. Complex 1 was found to exhibit effective antidiabetic activity among the tested compounds.

Keywords

Water soluble Zinc(II) complexes (E)-N-(thiophen-2-ylmethylene)aniline Antidiabetic activity
Paria, D., Kundu, S., Singh, K. K., Singh, S. S., & Singh, K. S. (2018). Synthesis, Characterization and Antidiabetic Activity of Some Water Soluble Zn(II) Complexes with (E)-N-(Thiophen-2-ylmethylene)anilines. Asian Journal of Chemistry, 30(5), 1115–1119. https://doi.org/10.14233/ajchem.2018.21216
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