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Vol. 30 No. 3 (2018): Vol 30 Issue 3

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Synthesis and Structural Elucidation of Novel 2,4-Disubstituted 1,3-Oxazole Analogues for Pharmacological Properties

https://doi.org/10.14233/ajchem.2018.21158
Katharigatta N. Venugopala
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Kingdom of Saudi Arabia; Department of Biotechnology and Food Technology, Durban University of Technology, Steve Biko Campus, Durban 4001, South Africa

Corresponding Author(s) : Katharigatta N. Venugopala

kvenugopala@kfu.edu.sa

Asian Journal of Chemistry, Vol. 30 No. 3 (2018): Vol 30 Issue 3

Abstract

A series of novel 2,4-disubstituted 1,3-oxazole analogues (3a-i) has been designed and synthesized between 1-[3,5-bis(trifluoromethyl)-phenyl]-2-bromoethan-1-one and substituted amides by microwave assisted method. 2,4-Disubstituted 1,3-oxazole analogues obtained were at excellent yields and purity of the compound was ascertained by HPLC. The chemical structure of these compounds was elucidated by spectrometric (FT-IR, NMR and LCMS) and elemental analysis. It was observed that, microwave method influenced the better yield and reduction in reaction time when compared to conventional reflux method.

Keywords

Oxazole analogues Synthesis Microwave method Spectrometric analyses Pharmacological activity
Venugopala, K. N. (2018). Synthesis and Structural Elucidation of Novel 2,4-Disubstituted 1,3-Oxazole Analogues for Pharmacological Properties. Asian Journal of Chemistry, 30(3), 684–688. https://doi.org/10.14233/ajchem.2018.21158
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