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Vol. 30 No. 3 (2018): Vol 30 Issue 3

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Synthesis of Schiff Base (E)-2-(((3-Hydroxyphenyl)imino)methyl)-6-methoxyphenol Containing N and O Donors and its Metal Complexes: Spectral, Thermal, Redox Behaviour, Fluorescence Quenching, Antimicrobial and Anticancer Studies

https://doi.org/10.14233/ajchem.2018.21085
G. Valarmathy
PG and Research Department of Chemistry, Seethalakshmi Ramaswami College, Tiruchirappalli-620 002, India
R. Subbalakshmi
PG and Research Department of Chemistry, Seethalakshmi Ramaswami College, Tiruchirappalli-620 002, India
R. Renganathan
School of Chemistry, Bharathidasan University, Tiruchirappalli-620 024, India
R. Kokila
PG and Research Department of Chemistry, Seethalakshmi Ramaswami College, Tiruchirappalli-620 002, India

Corresponding Author(s) : G. Valarmathy

valarchola@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 3 (2018): Vol 30 Issue 3

Abstract

Convenient synthesis of new octahedral complexes from 3-aminophenol and 2-hydroxy-3-methoxybenzaldehyde with the molecular formula [M(L2-2H)] (where M = Mn2+ and Co2+) have been described. The Schiff base behaves as a tridentate ligand with O and N donors and coordinates to metal ion via phenolic oxygens and azomethine nitrogen. The compositions of the ligand and its metal complexes have been established by elemental analysis and metal estimation. The ionic nature of the metal complexes has been deduced from conductance measurements. Structural features and bonding mode of Schiff base have been proposed by magnetic properties and spectral methods. Both the complexes exhibit d-d transitions, photo emissive and redox behaviour. The Schiff base ligand and its metal complexes have been screened for antimicrobial evaluation towards some clinically important microorganisms. The quenching studies were carried out for the [Co(L2-2H)] complex by alizarin red S dye in DMSO using fluorescence measurements. The evaluated highly biologically active [Co(L2-2H)] complex shows excellent cytotoxicity towards (MCF-7) cancer cell line.

Keywords

Schiff base ligand 3-Amino phenol 2-Hydroxy-3-methoxybenzaldehyde Fluorescent quenching Biological activities
Valarmathy, G., Subbalakshmi, R., Renganathan, R., & Kokila, R. (2018). Synthesis of Schiff Base (E)-2-(((3-Hydroxyphenyl)imino)methyl)-6-methoxyphenol Containing N and O Donors and its Metal Complexes: Spectral, Thermal, Redox Behaviour, Fluorescence Quenching, Antimicrobial and Anticancer Studies. Asian Journal of Chemistry, 30(3), 645–650. https://doi.org/10.14233/ajchem.2018.21085
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