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Vol. 30 No. 3 (2018): Vol 30 Issue 3

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Synthesis, Characterization and in vitro Antitubercular Evaluation of Some Schiff Bases of Substituted Indoles and their Inclusion Complexes with b-Cyclodextrin

https://doi.org/10.14233/ajchem.2018.20986
Pramoda Kumar Das
P.G. Department of Chemistry, Berhampur University, Bhanja Bihar-760 007, India
Rabinarayana Sahu
P.G. Department of Chemistry, Berhampur University, Bhanja Bihar-760 007, India
Prakasini Satapathy
ICMR-Tuberculosis Laboratory, Regional Medical Research Center, Bhubaneswar-751 023, India
Dasarathi Dash
ICMR-Tuberculosis Laboratory, Regional Medical Research Center, Bhubaneswar-751 023, India
Bamakanta Garnaik
P.G. Department of Chemistry, Berhampur University, Bhanja Bihar-760 007, India

Corresponding Author(s) : Bamakanta Garnaik

bama_61@rediffmail.com

Asian Journal of Chemistry, Vol. 30 No. 3 (2018): Vol 30 Issue 3

Abstract

Indole derivatives are best known for their biological importance as bactericides and fungicides which encouraged us to synthesize some Schiff bases of substituted indoles i.e. 2(([1,3,4]thiadiazino[6,5-b]indol-3-ylimino)methyl)substituted phenols. The synthesized compounds are found to exhibit antitubercular activities. With a view to enhance solubility induced potential anti tubercular activities, these synthesized compounds are encapsulated with b-cyclodextrin. Through elemental and spectral (UV, IR, 1H NMR) characterization, the architecture of the compounds and their inclusion complexes are confirmed. They are also screened for in vitro antitubercular activities by using rifampicin as the reference standard. The synthesized compounds exhibited good antitubercular activity but their inclusion complexes exhibited profound antitubercular activities as compared to their respective compounds.

Keywords

Schiff bases Inclusion complex Antitubercular activity b-Cyclodextrin
Das, P. K., Sahu, R., Satapathy, P., Dash, D., & Garnaik, B. (2018). Synthesis, Characterization and in vitro Antitubercular Evaluation of Some Schiff Bases of Substituted Indoles and their Inclusion Complexes with b-Cyclodextrin. Asian Journal of Chemistry, 30(3), 556–560. https://doi.org/10.14233/ajchem.2018.20986
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