Synthesis and Antibacterial Study of Thymol Derivatives

Nurul Hazwani Che Abdul Rahim; Asnuzilawati Asari; Noraznawati Ismail; Fauziah Abdullah; Hasnah Osman; Soraya Shafawati Mohamad Tahier

doi:10.14233/ajchem.2018.20933

Issue

Vol. 30 No. 1 (2018): Vol 30 Issue 1

Issue Published : November 30, 2017

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Antibacterial Study of Thymol Derivatives

https://doi.org/10.14233/ajchem.2018.20933

Nurul Hazwani Che Abdul Rahim

School of Fundamental Science, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia

Asnuzilawati Asari

School of Fundamental Science, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia

Noraznawati Ismail

Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia

Fauziah Abdullah

Phytochemistry Programme, Natural Product Division, Forest Research Institute Malaysia, 52109 Kepong, Selangor, Malaysia

Hasnah Osman

School of Chemical Science, Universiti Sains Malaysia, 11800 Pulau Pinang, Malaysia

Soraya Shafawati Mohamad Tahier

School of Fundamental Science, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia

Corresponding Author(s) : Asnuzilawati Asari

asnu@umt.edu.my

Asian Journal of Chemistry, Vol. 30 No. 1 (2018): Vol 30 Issue 1
Article Published : November 30, 2017

Abstract

Five thymol derivatives (2-6) were synthesized and evaluated for their antibacterial activity against four bacterial strains i.e., Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli using standard well-diffusion method.

Keywords

Thymol derivatives Antibacterial activity Well-diffusion method

Abdul Rahim, N. H. C., Asari, A., Ismail, N., Abdullah, F., Osman, H., & Mohamad Tahier, S. S. (2017). Synthesis and Antibacterial Study of Thymol Derivatives. Asian Journal of Chemistry, 30(1), 126–128. https://doi.org/10.14233/ajchem.2018.20933

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References

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P.P. Kumbhar and P.M. Dewang, J. Sci. Ind. Res. (India), 60, 645 (2001).
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References

A. Marchese, I.E. Orhan, M. Daglia, R. Barbieri,A. Di Lorenzo, S.F. Nabavi, O. Gortzi, M. Izadi and S.M. Nabavi, Food Chem., 210, 402 (2016); https://doi.org/10.1016/j.foodchem.2016.04.111.

A.A.E. Ibrahim, Am. J. Biol. Life Sci., 2, 154 (2014).

A. Özkan and A. Erdogan, Turk. J. Biol., 35, 735 (2011) https://doi.org/10.3906/biy-1011-170.

M. Boskovic, N. Zdravkovic, J. Ivanovic, J. Janjic, J. Djordjevic, M. Starcevic and M.Z. Baltic, Procedia Food Sci., 5, 18 (2015); https://doi.org/10.1016/j.profoo.2015.09.005.

N. Didry, L. Dubreuil and M. Pinkas, Pharm. Acta Helv., 69, 25 (1994); https://doi.org/10.1016/0031-6865(94)90027-2.

S.M. de Morais, N.S. Vila-Nova, C.M.L. Bevilaqua, F.C. Rondon, C.H. Lobo, A. de Alencar Araripe Noronha Moura, A.D. Sales, A.P.R. Rodrigues, J.R. de Figuereido, C.C. Campello, M.E. Wilson and H.F. de Andrade Jr., Bioorg. Med. Chem., 22, 6250 (2014); https://doi.org/10.1016/j.bmc.2014.08.020.

K.R. Riella, R.R. Marinho, J.S. Santos, R.N. Pereira-Filho, J.C. Cardoso, R.L.C. Albuquerque-Junior and S.M. Thomazzi, J. Ethnopharmacol., 143, 656 (2012); https://doi.org/10.1016/j.jep.2012.07.028.

A. Anderson, Int. J. Toxicol., 25, 29 (2006); https://doi.org/10.1080/10915810600716653.

V.B. Silva, D.L. Travassos, A. Nepel, A. Barison, E.V. Costa, L. Scotti, M.T. Scotti, R.J.B. Mendonca-Junior, R.C. Santos and S.C. Cavalcanti, J. Arthropod Borne Dis., 11, 315 (2017);

I. Karpouhtsis, E. Pardali, E. Feggou, S. Kokkini, Z.G. Scouras and P. Mavragani-Tsipidou, J. Agric. Food Chem., 46, 1111 (1998); https://doi.org/10.1021/jf970822o.

N.H.C. Abdul Rahim,A. Asari, N. Ismail and H. Osman, Asian J. Chem., 29, 22 (2017); https://doi.org/10.14233/ajchem.2017.20100.

P.P. Kumbhar and P.M. Dewang, J. Sci. Ind. Res. (India), 60, 645 (2001).

N. Raman, S. Thalamuthu, J.D. Raja, M.A. Neelakandan and S. Banerjee, J. Chil. Chem. Soc., 53, 1450 (2008); https://doi.org/10.4067/S0717-97072008000100025.

Issue

Vol. 30 No. 1 (2018): Vol 30 Issue 1

Synthesis and Antibacterial Study of Thymol Derivatives

Corresponding Author(s) : Asnuzilawati Asari

Abstract

Keywords

Full Article

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References

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