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Vol. 30 No. 1 (2018): Vol 30 Issue 1

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in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite

https://doi.org/10.14233/ajchem.2018.20856
I.M.W.A. Putra
Faculty of Health, Science and Technology, University of Dhyana Pura, Badung, Bali, Indonesia
K.W. Sitanggang
Department of Chemistry, Faculty of Mathematic and Natural Sciencies, University of Udayana, Badung, Bali, Indonesia
Putu Suarya
Department of Chemistry, Faculty of Mathematic and Natural Sciencies, University of Udayana, Badung, Bali, Indonesia
I.N. Simpen
Department of Chemistry, Faculty of Mathematic and Natural Sciencies, University of Udayana, Badung, Bali, Indonesia
Indra Cipta
Department of Chemistry Education, Faculty of Teacher Training and Education, Khairun University, Ternate, Indonesia

Corresponding Author(s) : I.M.W.A. Putra

made_wisnu84@yahoo.com

Asian Journal of Chemistry, Vol. 30 No. 1 (2018): Vol 30 Issue 1

Abstract

In this work, metformin HCl was encapsulated on citric acid activated montmorillonite as drug delivery system. The as-synthetized drug delivery systems were characterized by using FTIR and X-ray diffraction. FTIR spectra showed the presence of bending vibration of N-H from primary amines group and streching vibration of C=N at 1635.64 and 1506.41 cm-1, respectively. X-ray diffraction pattern also showed a widening of the diffraction peaks of montmorillonite after encapsulated by metformin HCl. In vitro drug release results showed that the release of metformin HCl from the drug delivery system in simulated intestinal fluid (pH 7.4) higher than that in simulatied gastric fluid (pH 1.2) with a value of drug release of 61.44 % and 39.41 %. Metformin HCl release kinetics at each pH follow the zero-order model (pH 1.2 with R = 0.9924; pH 7.4 with R = 0.9972) suggested diffusion-controlled release mechanism.

Keywords

Drug delivery system Encapsulation Montmorillonite Metformin HCl Controlled release
Putra, I., Sitanggang, K., Suarya, P., Simpen, I., & Cipta, I. (2017). in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite. Asian Journal of Chemistry, 30(1), 63–65. https://doi.org/10.14233/ajchem.2018.20856
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References
  1. H. Ito, H. Ishida, Y. Takeuchi, S. Antoku, M. Abe, M. Mifune and M. Togane, Nutr. Metab., 7, 83 (2010); https://doi.org/10.1186/1743-7075-7-83.
  2. S.E. Inzucchi, K.J. Lipska, H. Mayo, C.J. Bailey and D.K. McGuire, JAMA, 312, 2668 (2014); https://doi.org/10.1001/jama.2014.15298.
  3. G.G. Graham, J. Punt, M. Arora, R.O. Day, M.P. Doogue, J.K. Duong, T.J. Furlong, J.R. Greenfield, L.C. Greenup, C.M. Kirkpatrick, J.E. Ray, P. Timmins and K.M. Williams, Clin. Pharmacokinet., 50, 81 (2011); https://doi.org/10.2165/11534750-000000000-00000.
  4. A.K. Nayak, D. Pal and K. Santra, Carbohydr. Polym., 103, 154 (2014); https://doi.org/10.1016/j.carbpol.2013.12.031.
  5. R. Wang, Y. Peng, M. Zhou and D. Shou, Appl. Clay Sci., 134, 50 (2016); https://doi.org/10.1016/j.clay.2016.05.004.
  6. K.G. Bhattacharyya and S.S. Gupta, Adv. Colloid Interface Sci., 140, 114 (2008); https://doi.org/10.1016/j.cis.2007.12.008.
  7. S. Li, C. Jiang, X. Chen, H. Wang and J. Lin, Food Res. Int., 64, 822 (2014); https://doi.org/10.1016/j.foodres.2014.08.030.
  8. M. Mahmoudi, M. Adib-Hajbaghery and M. Mashaiekhi, Indian J. Med. Res., 142, 742 (2015); https://doi.org/10.4103/0971-5916.174567.
  9. N. Meng, N. Zhou, S. Zhang and J. Shen, Int. J. Pharm., 382, 45 (2009); https://doi.org/10.1016/j.ijpharm.2009.08.004.
  10. K. Saha, B.S. Butola and M. Joshi, Appl. Clay Sci., 101, 477 (2014); https://doi.org/10.1016/j.clay.2014.09.010.
  11. M.G. Apps, A.J. Ammit,A. Gu and N.J. Wheate, Inorg. Chim. Acta, 421, 513 (2014); https://doi.org/10.1016/j.ica.2014.07.009.
  12. M. Rabiei, H. Sabahi and A.H. Rezayan, Appl. Clay Sci., 119, 236 (2016); https://doi.org/10.1016/j.clay.2015.10.020.
  13. A. Rapacz-Kmita, M.M. Bucko, E. Stodolak-Zych, M. Mikolajczyk, P. Dudek and M. Trybus, Mater. Sci. Eng. C, 70, 471 (2017); https://doi.org/10.1016/j.msec.2016.09.031.
  14. A. Khan, S.H.J. Naqvi, M.A. Kasmi and Z. Ashraf, Sci. Int. (Lahore), 27, 329 (2015).
  15. G.V. Joshi, H.A. Patel, B.D. Kevadiya and H.C. Bajaj, Appl. Clay Sci., 45, 248 (2009); https://doi.org/10.1016/j.clay.2009.06.001.
  16. I.M.W.A. Putra and I.G. Mustika, Chakra Kimia, 4, 103 (2016).
  17. M. Hosseinpour, S.J. Ahmadi,A. Charkhi and S.A. Allahyari, J. Supercrit. Fluids, 95, 236 (2014); https://doi.org/10.1016/j.supflu.2014.08.018.
  18. Ö. Egri, K. Salimi, S. Egri, E. Piskin and Z.M.O. Rzayev, Carbohydr. Polym., 137, 111 (2016); https://doi.org/10.1016/j.carbpol.2015.10.043.
  19. C. Wang, C. He, Z. Tong, X. Liu, B. Ren and F. Zeng, Int. J. Pharm., 308, 160 (2006); https://doi.org/10.1016/j.ijpharm.2005.11.004.
  20. R.I. Iliescu, E. Andronescu, C.D. Ghitulica, G. Voicu, A. Ficai and M. Hoteteu, Int. J. Pharm., 463, 184 (2014); https://doi.org/10.1016/j.ijpharm.2013.08.043.
  21. J.P. Zheng, L. Luan, H.Y. Wang, L.F. Xi and K.D. Yao, Appl. Clay Sci., 36, 297 (2007); https://doi.org/10.1016/j.clay.2007.01.012.
  22. T.S. Anirudhan, S.S. Gopal and S. Sandeep, Appl. Clay Sci., 88-89, 151 (2014); https://doi.org/10.1016/j.clay.2013.11.039.
  23. D. Hou, S. Hu, Y. Huang, R. Gui, L. Zhang, Q. Tao, C. Zhang, S. Tian, S. Komarneni and Q. Ping, Appl. Clay Sci., 119, 277 (2016); https://doi.org/10.1016/j.clay.2015.10.028.
  24. S. Jain and M. Datta, J. Drug Deliv. Sci. Technol., 33, 149 (2016); https://doi.org/10.1016/j.jddst.2016.04.002.
  25. Y. Kamari, P. Ghiaci and M. Ghiaci, Mater. Sci. Eng. C, 75, 822 (2017); https://doi.org/10.1016/j.msec.2017.02.115.
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