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Vol. 30 No. 12 (2018): Vol 30 Issue 12

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Spectrophotometric Determination for Benzodiazepine Drugs (Clonazepam and Nitrazepam) in Pure and Pharmaceuticals Preparation

https://doi.org/10.14233/ajchem.2018.21549
Muna Iskandar Mahdi
Department of Chemistry, College of Science, Babylon University, Hilla 51002, Iraq
Kassim Hassan Kadim
Department of Chemistry, College of Science, Babylon University, Hilla 51002, Iraq

Corresponding Author(s) : Muna Iskandar Mahdi

esk.muna44@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 12 (2018): Vol 30 Issue 12

Abstract

Depending on the oxidative coupling reaction as a rapid and selective spectrophotometric method, reduced clonazepam and nitrazepam drugs were evaluated by using potassium bromate as oxidation agent for these drugs and phenylephrine hydrochloride as a new chromogenic reagent to give red coloured products for clonazepam and nitrazepam at a maximum absorption of 491 and 488 nm, respectively. The linear ranges was 2-60 μg mL-1 and 5-90 μg mL-1 while the molar absorptivity are 3.157 × 103 L mol-1 cm-1 and 3.825 × 103 L mol-1 cm-1 and their detection limits are 0.141 μg mL-1 and 0.104 μg mL-1, respectively for clonazepam and nitrazepam. The proposed methods did not require any temperature control and also not affected by foreign excipients and henceforth successfully applied to determine clonazepam and nitrazepam in pharmaceutical preparations.

Keywords

Spectrophotometric determination Benzodiazepine drugs Clonazepam Nitrazepam Oxidative coupling reaction
Mahdi, M. I., & Kadim, K. H. (2018). Spectrophotometric Determination for Benzodiazepine Drugs (Clonazepam and Nitrazepam) in Pure and Pharmaceuticals Preparation. Asian Journal of Chemistry, 30(12), 2686–2692. https://doi.org/10.14233/ajchem.2018.21549
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References
  1. A. Moffat, M. Osselton and B. Widdop, Clarkes Analysis of Drugs and Poisons, Pharmaceutical Press: London, edn 4 (2011).
  2. C. Fleeger, USAN and The USP Dictionary of Drug Names, United States Pharmacopeial Convention, Inc.: USA (1992).
  3. K. Parfitt and W. Martindale, Martindale the Complete Drug Reference, Pharmaceutical Press: London, edn 32 (1999).
  4. K.H. Kadhim, A.N. Al-Shirifi and A.S. Abbas, Kerbala J. Pharm. Sci., 9, 39 (2015).
  5. P.J. Cowen, A.R. Green, D.J. Nutt and I.L. Martin, Nature, 290, 54 (1981); https://doi.org/10.1038/290054a0.
  6. T. Browne, J. Hosp. Pharm., 35, 1048 (1978).
  7. A. Wilson, H. Schild and W. Modell, Applied Pharmacologh, Churchill Livingstone: London, edn 11 (1975).
  8. B. Katzung, Basic and Clinical Pharmacology, McGraw-Hill Companies, Inc.: USA, edn 10, p. 475 (2007).
  9. R. Mallikarjuna, N. Agarwal, P. Bichala and S. Som, Indian J. Res. Pharm. Biotechnol., 1, 525 (2013).
  10. T. Bhagyasree, I. Neelam and A. Ajitha, J. Pharm. Res. Anal., 4, 421 (2014).
  11. N. Rani, G. Sahithi and K. Divya, J. Pharm. Sci. Drug Res., 7, 182 (2015).
  12. P. Ho, E. Triggs, V. Heazlewood and D. Bourne, Ther. Drug Monit., 5, 303 (1983); https://doi.org/10.1097/00007691-198309000-00010.
  13. T. Kozu, J. Chromatogr., Biomed. Appl., 310, 213 (1984); https://doi.org/10.1016/0378-4347(84)80085-7.
  14. K. Suzuki, I. Johno and S. Kitazawa, J. Chromatogr., Biomed. Appl., 425, 435 (1988); https://doi.org/10.1016/0378-4347(88)80052-5.
  15. C. Le Guellec, M.L. Gaudet and M. Breteau, J. Chromatogr. B, Biomed. Appl., 719, 227 (1998); https://doi.org/10.1016/S0378-4347(98)00391-0.
  16. M.-E. Capella-Peir, D. Bose, A. Martinavarro-Domínguez, M. Gil-Agust and J. Esteve-Romero, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 780, 241 (2002); https://doi.org/10.1016/S1570-0232(02)00523-8.
  17. R. Sane, U. Ghorpade, A. Nadkarni and S. Dolas, Indian Drugs, 24, 260 (1987).
  18. T. Gunnar, K. Ariniemi and P. Lillsunde, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 818, 175 (2005); https://doi.org/10.1016/j.jchromb.2004.12.032.
  19. A. Salem, B. Barsoum and E. Izake, Spectrochim Acta, 60, 771 (2004); https://doi.org/10.1016/S1386-1425(03)00300-7.
  20. R. Kakde, D. Satone, K. Gadapayale and M. Kakde, J. Chromatogr. Sci., 51, 490 (2013); https://doi.org/10.1093/chromsci/bms177.
  21. M. Wilhelm, H. Battista and D. Obendorf, J. Chromatogr. A, 897, 215 (2000); https://doi.org/10.1016/S0021-9673(00)00806-2.
  22. L.E. Cavedal, F.D. Mendes, C.C. Domingues, A.K. Patni, T. Monif, S. Reyar, A.S. Pereira, G.D. Mendes and G. De Nucci, J. Mass Spectrom., 42, 81 (2007); https://doi.org/10.1002/jms.1141.
  23. S. Gandhi, N. Dhavale, V. Jadhav and S. Sabnis, J. AOAC Int., 91, 33 (2008).
  24. M. Pujadas, S. Pichini, E. Civit, E. Santamariña, K. Perez and R. de la Torre, J. Pharm. Biomed. Anal., 44, 594 (2007); https://doi.org/10.1016/j.jpba.2007.02.022.
  25. J. Gu, N. Chen, J. Yan, T. Huang, D. Wang and Y. Lai, Chromatographia, 70, 1709 (2009); https://doi.org/10.1365/s10337-009-1372-9.
  26. H. Dai, Y. Lin, X. Wu and G. Chen, Sens. Actuators A Phys., 145, 320 (2010); https://doi.org/10.1016/j.snb.2009.12.004.
  27. M. Chaichi and S. Alijanpour, J. Lumines., 134, 195 (2013); https://doi.org/10.1016/j.jlumin.2012.08.048.
  28. R. Jain, R. Mishra and A. Dwivedi, J. Sci. Ind. Res. (India), 68, 540 (2009).
  29. H. Hanekamp, W. Voogt, P. Bos and R. Frei, J. Liq. Chromatogr. Rel. Technol., 3, 1205 (1980); https://doi.org/10.1080/01483918008064752.
  30. A. Mishra and K. Gode, Analyst, 110, 1105 (1985); https://doi.org/10.1039/an9851001105.
  31. M. Tomita and T. Okuyama, J. Chromatogr. B Biomed. Appl., 678, 331 (1996); https://doi.org/10.1016/0378-4347(95)00512-9.
  32. A. Wozniakiewicz, R. Wietecha-Posluszny, M. Wozniakiewicz, E. Bryczek and P. Koœcielniak, J. Pharm. Biomed. Anal., 111, 177 (2015); https://doi.org/10.1016/j.jpba.2015.03.029.
  33. K. Honeychurch, J. Brooks and J. Hart, Talanta, 147, 510 (2016); https://doi.org/10.1016/j.talanta.2015.10.032.
  34. B. Habibi and M. Jahanbakhshi, Electrochim. Acta, 118, 10 (2014); https://doi.org/10.1016/j.electacta.2013.11.169.
  35. S. Halvorsen and E. Jacobsen, Anal. Chim. Acta, 59, 127 (1972); https://doi.org/10.1016/S0003-2670(01)84832-7.
  36. A.E.A. Salem, B.N. Barsoum, G.R. Saad and E.L. Izake, J. Electroanal. Chem., 536, 1 (2002); https://doi.org/10.1016/S0022-0728(02)01147-6.
  37. E. Ruiz, M. Blanco, E. Abad and L. Hernández, Analyst, 112, 697 (1987); https://doi.org/10.1039/AN9871200697.
  38. J. Dolejs’ova, P. Solich, C. Polydorou, M. Koupparis and C. Efstathiou, J. Pharm. Biomed. Anal., 20, 357 (1999); https://doi.org/10.1016/S0731-7085(99)00064-3.
  39. M. Al-Abachi and M. Hammoudi, Iraqi J. Sci., 56, 898 (2015)
  40. M. Al-Abachi and M. Hammoudi, Iraqi J. Sci., 56, 2115 (2015).
  41. R. Abdulsattar, J. Univ. Anbar Pure Sci., 4, 1991 (2010).
  42. M. Al-Abachi and H. Hadi, Al-Mustansiriyah J. Sci., 26, 38 (2015).
  43. S.R. El-Shabouri, Talanta, 33, 743 (1986); https://doi.org/10.1016/0039-9140(86)80177-1.
  44. M. Walash, M. Rizk and A. El-Brashy, Talanta, 35, 895 (1988); https://doi.org/10.1016/0039-9140(88)80209-1.
  45. S. Hassan, F. Belal, M. El-Din and M. Sultan, Analyst, 113, 1087 (1988); https://doi.org/10.1039/an9881301087.
  46. S. Abdul Satar, Iraqi J. Biotechnol., 8, 252 (2009).
  47. A.G. Davidson and H.W. Li, J. Pharm. Pharmacol., 41, 63 (1989); https://doi.org/10.1111/j.2042-7158.1989.tb06333.x.
  48. T. Al-Ghabsha, A. Azooz and A. Namir, J. Educ. Sci., 21, 147 (2008).
  49. A. El-Brashy, F.A. Aly and F. Belal, Mikrochim. Acta, 110, 55 (1993); https://doi.org/10.1007/BF01243985.
  50. H.N. Deepakumari and H.D. Revanasiddappa, J. Spectrosc., Article ID 671689 (2013); https://doi.org/10.1155/2013/671689.
  51. F. Randez-Gil, J. Daros, A. Salvador and M. De La Guardia, J. Pharm. Biomed. Anal., 9, 539 (1991); https://doi.org/10.1016/0731-7085(91)80175-9.
  52. P. Thampi and K. Premnath, Indian Drugs, 23, 239 (1986).
  53. I. Popovici, V. Dorneanu, M. Stan and R. Cuciureanu, Rev. Chim. (Bucharest), 35, 266 (1984).
  54. H. Revanasiddappa, H. Deepakumari, S. Mallegowda and K.B. Vinay, Anal. Univ. Bucuresti, 20,189 (2011).
  55. R. Sinan, M. Al-Abachi, J. Univ. Anbar Pure Sci., 3, 6 (2009).
  56. H. Abdullah, Bull. Chem. Soc. Ethiop., 31, 373 (2017); https://doi.org/10.4314/bcse.v31i3.2.
  57. Y. Al-Shaker and I. Hasan, Raf. J. Sci., 22, 39 (2011).
  58. K. Upadhyay, Recent Res. Sci. Technol., 4, 89 (2012).
  59. S. Ali and K. Kadhim, Int. J. Chemtech Res., 10, 749 (2017).
  60. H. Hadi, Iraqi J. Pharm Sci., 24, 25 (2015).
  61. B. Gowda, M. Melwanki and J. Seetharamappa, Anal. Sci., 17, 533 (2001); https://doi.org/10.2116/analsci.17.533.
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