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Vol. 30 No. 10 (2018): Vol 30 Issue 10, 2018

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Comparative in silico and in vivo Analgesic and Anti-Inflammatory Activities of Some Novel Schiff Bases of Isatin

https://doi.org/10.14233/ajchem.2018.21406
P.P. Chinchole
Department of Chemistry, Dr. D.Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune-411 018, India
S.B. Wankhede
Department of Chemistry, J.S.P.M's Charak College of Pharmacy and Research, Wagholi, Pune-412 207, India

Corresponding Author(s) : P.P. Chinchole

pavanchinchole@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 10 (2018): Vol 30 Issue 10, 2018

Abstract

The objective of this study is to synthesize the different derivatives of isatin and pyrazole on Schiff base mechanism, which on subjected to docking study by AUTODOCK TOOL software. in vitro and in vivo analgesic and anti-inflammatory activities were performed on the compound showing the optimum docking results selected on the basis of binding energy.

Keywords

Isatin Pyrazole Schiff base Analgesic activity Anti-inflammatory activity Docking study
Chinchole, P., & Wankhede, S. (2018). Comparative in silico and in vivo Analgesic and Anti-Inflammatory Activities of Some Novel Schiff Bases of Isatin. Asian Journal of Chemistry, 30(10), 2220–2224. https://doi.org/10.14233/ajchem.2018.21406
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