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Vol. 27 No. 12 (2015): Vol 27 Issue 12

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Monotropically More Stable Novel Polymorph of Nitazoxanide with Improved Aqueous Solubility

https://doi.org/10.14233/ajchem.2015.19161
Sri Rama Chandra Murthy Patnala
Neuland Laboratories Limited, Sanali Info Park, Road No. 2, Banjara Hills, Hyderabad-500 034, India; Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500 085, India; Green Evolution Laboratories, Wangapally Village, Nalgonda-500 085, India
Mukkanti Khagga
Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500 085, India
Ram Bhavani
Green Evolution Laboratories, Wangapally Village, Nalgonda-500 085, India

Corresponding Author(s) : Ram Bhavani

ram_19_73@yahoo.co.in

Asian Journal of Chemistry, Vol. 27 No. 12 (2015): Vol 27 Issue 12

Abstract

Nitazoxanide [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate] is a drug used for antiprotozoal treatment. This drug belongs to biopharmaceutics classification system (II) and presently available in two high oral dosage forms-tablet (500 mg) and oral suspension (100 mg per 5 mL when reconstituted). A monotropically more stable novel polymorphic form (Form II) of nitazoxanide with improved aqueous solubility has been identified and fully characterized by a variety of analytical techniques such as powder X-ray diffraction, differential scanning calorimeter, thermogravimetric analysis, Karl Fischer titration, infrared spectroscopy, solution state nuclear magnetic resonance, polarized microscopy and high performance liquid chromatography techniques. Aqueous solubility of Form II is increased by 2.76 folds. Form II is obtained from less toxic and environment friendly Class III organic solvent ethanol.

Keywords

Polymorphs Nitazoxanide Antiparastic agent Aqueous solubility Powder X-ray diffraction
Rama Chandra Murthy Patnala, S., Khagga, M., & Bhavani, R. (2015). Monotropically More Stable Novel Polymorph of Nitazoxanide with Improved Aqueous Solubility. Asian Journal of Chemistry, 27(12), 4425–4428. https://doi.org/10.14233/ajchem.2015.19161
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