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Vol. 36 No. 1 (2024): Vol 36 Issue 1, 2024

Copyright (c) 2023 Tirth Thaker, Sweta Maurya, Dipen Panchani

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Antimicrobial Screening and ADME Investigations of Novel Bi-Heterocycles containing Benzopyrones with Pyrazolone

https://doi.org/10.14233/ajchem.2024.30754
Tirth Thaker
Department of Chemistry, Parul Institute of Applied Sciences, Parul University, Vadodara-391760, India
https://orcid.org/0000-0003-3141-214X
Sweta Maurya
Department of Chemistry, Parul Institute of Applied Sciences, Parul University, Vadodara-391760, India
Dipen Panchani
Department of Chemistry, Parul Institute of Applied Sciences, Parul University, Vadodara-391760, India
https://orcid.org/0009-0000-8837-5680

Corresponding Author(s) : Tirth Thaker

tirth.thaker82094@paruluniversity.ac.in

Asian Journal of Chemistry, Vol. 36 No. 1 (2024): Vol 36 Issue 1, 2024

Abstract

Few 3-methyl-1-2-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]acetyl-4,5-dihydro-1H-pyrazol-5-one derivatives were synthesized and their structures were characterized by FTIR, 1H NMR and mass spectrometry. To assess the potential antibacterial action of a conventional medicine, a biological screening was done on Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa. Furthermore, these medicines underwent in silico ADME evaluation. Although all compounds successfully underwent the ADME  evaluation, only a limited number of compounds passed the projected toxicity test.

Keywords

7-Hydroxy-4-methyl-benzopyrone Cyclization Pyrazolone Antibacterial activity ADME studies
Thaker, T., Sweta Maurya, & Panchani, D. (2023). Synthesis, Antimicrobial Screening and ADME Investigations of Novel Bi-Heterocycles containing Benzopyrones with Pyrazolone. Asian Journal of Chemistry, 36(1), 184–188. https://doi.org/10.14233/ajchem.2024.30754
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