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Vol. 36 No. 1 (2024): Vol 36 Issue 1, 2024

Copyright (c) 2023 Arunsunai Kumar Karuppiah, Ramgeetha Lakshmanan

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Isoniazid-Crysin Incorporated Mixed Ligand Schiff Base Metal(II) Complexes: Synthesis, Spectral Investigation, DNA Binding and Antibacterial Studies

https://doi.org/10.14233/ajchem.2024.30678
L. Ramgeetha
Research Department of Chemistry, VHNSN College (Autonomous), (Affiliated to Madurai Kamaraj University, Madurai), Virudhunagar-626001, Indi
https://orcid.org/0000-0002-7881-6304
K. Arunsunai Kumar
Research Department of Chemistry, VHNSN College (Autonomous), (Affiliated to Madurai Kamaraj University, Madurai), Virudhunagar626001, Indi
https://orcid.org/0000-0002-7143-1524

Corresponding Author(s) : K. Arunsunai Kumar

arunsunaikumar@vhnsnc.edu.in

Asian Journal of Chemistry, Vol. 36 No. 1 (2024): Vol 36 Issue 1, 2024

Abstract

In present work, a novel isoniazid incorporated metal(II) complexes using chrysin as a co-ligand have been synthesized. The structural characterization of all the four transition metal(II) complexes [M = Co2+, Ni2+, Cu2+, Zn2+] were investigated by electronic absorption, infrared, 1H & 13C NMR, high resolution electron spray ionization-mass techniques and other physico-chemical parameters. The results revealed that the Schiff base metal complexes with mixed ligands have octahedral configurations. The antibacterial analysis  demonstrates that they have exceptional inhibitory efficacy against various bacterial and fungal strains. The DNA study reveals that the Schiff base metal(II) complexes with mixed ligands have intercalation type of binding. The DNA from calf thymus (ct-DNA) (PDB ID: 1BNA) was used for molecular docking studies to determine the likely binding location of the metal(II) complexes. The 3D structure of  the compounds was optimized using Gaussian 09 software 6-31G/B3LYP set and the DFT calculations were used to locate enzyme- inhibitory areas. 

Keywords

Isoniazid Chrysin Transition metal(II) complexes Mixed ligand DNA binding Antibacterial activity
Ramgeetha, L., & Arunsunai Kumar, K. (2023). Isoniazid-Crysin Incorporated Mixed Ligand Schiff Base Metal(II) Complexes: Synthesis, Spectral Investigation, DNA Binding and Antibacterial Studies. Asian Journal of Chemistry, 36(1), 109–119. https://doi.org/10.14233/ajchem.2024.30678
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