Issue

Vol. 27 No. 12 (2015): Vol 27 Issue 12

Copyright (c) 2015 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization and Toxicity Analysis of Some Mn(II), Co(II), Ni(II) and Cu(II) Complexes with N-p-Nitrobenzoyl-a-phenylalanine

https://doi.org/10.14233/ajchem.2015.19206
C. Rosca
Gheorghe Asachi Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, 73 D. Mangeron Rd., Iasi 700050, Romania
V. Sunel
Alexandru Ioan Cuza University of Iasi, Faculty of Chemistry, B-dul Carol I, Nr. 11, RO-700506-Iasi, Romania
M. Cretu
Alexandru Ioan Cuza University of Iasi, Faculty of Chemistry, B-dul Carol I, Nr. 11, RO-700506-Iasi, Romania
C. Mita
Alexandru Ioan Cuza University of Iasi, Faculty of Chemistry, B-dul Carol I, Nr. 11, RO-700506-Iasi, Romania
N. Apostolescu
Gheorghe Asachi Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, 73 D. Mangeron Rd., Iasi 700050, Romania
D. Mareci
Gheorghe Asachi Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, 73 D. Mangeron Rd., Iasi 700050, Romania
C. Munteanu
Gheorghe Asachi Technical University of Iasi, Faculty of Mechanical Engineering, 73 D. Mangeron Rd., Iasi 700050, Romania
I. Rusu
Gheorghe Asachi Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, 73 D. Mangeron Rd., Iasi 700050, Romania
D. Sibiescu
Gheorghe Asachi Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, 73 D. Mangeron Rd., Iasi 700050, Romania
C. Stan
Gheorghe Asachi Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, 73 D. Mangeron Rd., Iasi 700050, Romania
D. Sutiman
Gheorghe Asachi Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, 73 D. Mangeron Rd., Iasi 700050, Romania

Corresponding Author(s) : D. Sutiman

sutiman@ch.tuiasi.ro

Asian Journal of Chemistry, Vol. 27 No. 12 (2015): Vol 27 Issue 12

Abstract

The paper presents the synthesis and physico-chemical characterization of some Mn(II), Co(II), Ni(II) and Cu(II) complexes with N-p-nitrobenzoyl-a-phenylalanine and the determination of toxicity level (lethal dose). Elemental analysis, FTIR, UV-visible and XRD spectroscopy, electronic spin resonance (ESR), Mössbauer spectroscopy for the iron compound and the thermal stability with the FTIR analysis of the evolved gases were applied to characterize the metal complexes. All the compounds have an orthorhombic crystalline structure and have a thermal stability over 100 °C. The toxicity of the new compounds was tested on laboratory mice and was determined that Cu(II) compound has the lowest lethal dose compared with the pure ligand.

Keywords

N-(p-Nitrobenzoyl)-a-phenylalanine Coordination compounds Structure Thermal analysis Toxicity
Rosca, C., Sunel, V., Cretu, M., Mita, C., Apostolescu, N., Mareci, D., … Sutiman, D. (2015). Synthesis, Characterization and Toxicity Analysis of Some Mn(II), Co(II), Ni(II) and Cu(II) Complexes with N-p-Nitrobenzoyl-a-phenylalanine. Asian Journal of Chemistry, 27(12), 4510–4516. https://doi.org/10.14233/ajchem.2015.19206
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. F. Clerici, D. Pocar, M. Guido, A. Loche, V. Perlini and M. Brufani, J. Med. Chem., 44, 931 (2001); doi:10.1021/jm001027w.
  2. T. Onkol, B. Çakir and M.F. Sahin, J. Chem., 28, 461 (2004).
  3. A. Varvarason, A. Tantili-Kakoulidou, T. Siatra-Papastasikoudi and E. Tiligada, Arzneimittelforschung, 50, 48 (2000).
  4. M. Gökce, B. Çakir, K. Erol and M.F. Sahin, Arch. Pharm., 334, 279 (2001); doi:10.1002/1521-4184(200109)334:8/9<279::AID-ARDP279>3.0.CO;2-W.
  5. O. Pintilie, L. Profire, V. Sunel, M. Popa and A. Pui, Molecules, 12, 103 (2007); doi:10.3390/12010103.
  6. K. Zamani, K. Faghifi, I. Tefighi and M.R. Sharlatzadeh, Turk. J. Chem., 28, 95 (2004).
  7. X.-J. Zou, L.-H. Lai, G.-Y. Jin and Z.-X. Zhang, J. Agric. Food Chem., 50, 3757 (2002); doi:10.1021/jf0201677.
  8. H. Chen, Z. Li and Y. Han, J. Agric. Food Chem., 48, 5312 (2000); doi:10.1021/jf991065s.
  9. S. Schenone, O. Bruno, A. Ranise, F. Bondavalli, W. Filippelli, G. Falcone, L. Giordano and M.R. Vitelli, Bioorg. Med. Chem., 9, 2149 (2001); doi:10.1016/S0968-0896(01)00121-3.
  10. L. Labanauskas, V. Kalcas, E. Uderenaite, P. Gaidelis, A. Brukstus and V. Dauksas, Pharmazie, 56, 617 (2001).
  11. E. Palaska, G. Şahin, P. Kelicen, N.T. Durlu and G. Altinok, Farmaco, 57, 101 (2002); doi:10.1016/S0014-827X(01)01176-4.
  12. V. Sunel, C. Lionte, M. Popa, O. Pintilie, P. Mungiu and S. Teleman, Eur. Chem. Tech. J., 4, 201 (2002).
  13. O. Pintilie, V. Sunel, L. Profire and A. Pui, Farmacia, 55, 345 (2007).
  14. M. Moise, V. Sunel, L. Profire, M. Popa and C. Lionte, Farmacia, 56, 283 (2008).
  15. V. Sunel, C. Lionte, C. Basu and C. Cheptea, Chem. Indian J., 2, 1 (2005).
  16. V. Sunel, M. Popa, J. Desbrières, L. Profire, P. Otilia and L. Catalina, Molecules, 13, 177 (2008); doi:10.3390/molecules13010177.
  17. M. Yadav, D. Behera and U. Sharma, Corros. Eng. Sci. Technol., 48, 19 (2013); doi:10.1179/1743278212Y.0000000047.
  18. M. Moise, V. Sunel, L. Profire, M. Popa, J. Desbrieres and C. Peptu, Molecules, 14, 2621 (2009); doi:10.3390/molecules14072621.
  19. A.B.P. Lever, Inorganic Electronic Spectroscopy, Elsevier, New York, edn 2, p. 712 (1984).
  20. D.S. Bohle, A. Zafar, P.A. Goodson and D.A. Jaeger, Inorg. Chem., 39, 712 (2000); doi:10.1021/ic990950p.
  21. N.S. Bhave and R.B. Kharat, J. Inorg. Nucl. Chem., 43, 414 (1981); doi:10.1016/0022-1902(81)90041-5.
  22. N.A. Liu and W.C. Fan, Thermochim. Acta, 338, 85 (1999); doi:10.1016/S0040-6031(99)00197-5.
  23. L. Pauling, General Chemistry, Scientific Ed., Bucharest, p.183 (1972).
  24. N.I.S.T. Chemistry Webbook Standard Reference Database No, 69, June 2005 Release (http://webbook.nist.gov/chemistry).
  25. J. Madarász, I.M. Szilágyi, F. Hange and G. Pokol, J. Anal. Appl. Pyrolysis, 72, 197 (2004); doi:10.1016/j.jaap.2004.06.001.
  26. J. Madarász, P.P. Varga and G. Pokol, J. Anal. Appl. Pyrolysis, 79, 475 (2007); doi:10.1016/j.jaap.2006.12.024.
  27. O. Shulga and J. Dunn, Thermochim. Acta, 410, 15 (2004); doi:10.1016/S0040-6031(03)00370-8.
  28. L. Jie, L. Yuwen, S. Jingyan, W. Zhiyong, H. Ling, Y. Xi and W. Cunxin, Thermochim. Acta, 467, 20 (2008); doi:10.1016/j.tca.2007.10.014.
  29. N. Sasidharan, B. Hariharanath and A.G. Rajendran, Thermochim. Acta, 520, 139 (2011); doi:10.1016/j.tca.2011.03.031.
  30. S. Materazzi, S. Aquili, C. Bianchetti, G. D’Ascenzo, K.M. Kadish and J.L. Bear, Thermochim. Acta, 409, 145 (2004); doi:10.1016/S0040-6031(03)00356-3.
  31. S. Materazzi, S. Aquili, K. Kurdziel and S. Vecchio, Thermochim. Acta, 457, 7 (2007); doi:10.1016/j.tca.2007.02.016.
  32. E. Dommer, Animal Experiments in Pharmacological Analysis, Charles C. Thomas, Springfield, p. 283 (1971).
  33. M.A. Hamilton, R.C. Russo and R.V. Thurston, Environ. Sci. Technol., 12, 417 (1978); doi:10.1021/es60140a017.
  34. G.L. Gravatt, B.C. Baguley, W.R. Wilson and W.A. Denny, J. Med. Chem., 37, 4338 (1994); doi:10.1021/jm00051a010.
  35. N.M.A. El-Salam, N.S. Mostafa, G.A. Ahmed and O.Y. Alothman, Wulfenia, 3, 303 (2013).
  36. D. Mareci, R. Chelariu, I. Rusu, N. Melniciuc-Puica and D. Sutiman, Eur. J. Sci. Theol., 6, 57 (2010).
  37. D. Mareci, R. Chelariu, D. Sutiman and I. Rusu, Eur. J. Sci. Theol., 7, 121 (2011).
  38. D. Sutiman, I. Rusu, R. Chelariu, G. Lisa, V. Diaconescu and D. Mareci, Eur. J. Sci. Theol., 8, 215 (2012).
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0