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Vol. 31 No. 7 (2019): Vol 31 Issue 7

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Protein Misfolding, Associated Diseases and Potential Therapeutic Routes: A Mini Review

https://doi.org/10.14233/ajchem.2019.21940
Anisur R. Molla
Department of Chemistry, Bidhannagar College, Salt Lake, Kolkata-700064, India
https://orcid.org/0000-0002-4442-0643
Pritha Mandal
Department of Chemistry, Chandernagore College, Hooghly-712136, India
https://orcid.org/0000-0001-7867-5620

Corresponding Author(s) : Pritha Mandal

prithamandal@yahoo.com

Asian Journal of Chemistry, Vol. 31 No. 7 (2019): Vol 31 Issue 7

Abstract

Correctly folded proteins play key role in all biological reactions. Folding of protein into its native structure is the most astonishing example of biological self-assembly. Gene mutation, translational or transcriptional error, failure of chaperon mechanism results in misfolded protein structure. Misfolded proteins are responsible for a number of human diseases namely Alzheimer’s disease or Parkinson’s disease. Research for finding therapeutic breakthrough against these ailments has invoked different strategies.

Keywords

Misfolding Aggregation Neurodegenerative disease Native protein stabilizer β-Sheet blocker
Molla, A. R., & Mandal, P. (2019). Protein Misfolding, Associated Diseases and Potential Therapeutic Routes: A Mini Review. Asian Journal of Chemistry, 31(7), 1413–1418. https://doi.org/10.14233/ajchem.2019.21940
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