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Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Copyright (c) 2023 B. DURGA VARAPRASADU, K. SHIVA KUMAR, B. PULLA RAO

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Design, Synthesis, Characterization and Antibacterial Activity of Some Novel Furan Supported 1,2,4-Triazoles

https://doi.org/10.14233/ajchem.2023.27959
B. DURGA VARAPRASADU
Department of Chemistry, GITAM University, Hyderabad Campus, Rudraram Village, Patancheru Mandal, Medak-502329, India
https://orcid.org/0009-0007-3210-6212
K. SHIVA KUMAR
Department of Chemistry, GITAM University, Hyderabad Campus, Rudraram Village, Patancheru Mandal, Medak-502329, India
https://orcid.org/0000-0002-2586-4257
B. PULLA RAO
Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar, Guntur-522510, India
https://orcid.org/0009-0005-5965-0002

Corresponding Author(s) : B. DURGA VARAPRASADU

botlavaraprasadu@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Abstract

A methodical approach to synthesize several novel 2-phenyl-4-methylfuran [2,3-e][1,2,4]triazolo [1,5-c]pyrimidine derivatives (5a-c) as final compounds, N-(4-imino-4-methylfuro [2,3-d]pyrimidin-3(4H)-ylbenzamides (4a-c) by involving 2-amino-3-cyano-4-methyl furan (1) and N-(3-cyano-4-methylfuran)formimidic ethyl ether (2) and N’-((Z-(3-cyano-4-methylfuran-2-ylimino)methyl)benzohydrazides (3a-c) as intermediates and their antibacterial activity was tested. The chemical structures of all the newly synthesized intermediates and title compounds have been characterized by 1H NMR, IR, HRMS and elemental analysis. Compounds 4a-c and 5a-c showed antibacterial activity against different bacterial strains.

Keywords

Furan 1,2,4-triazole Antibacterial activity
VARAPRASADU, B. D., KUMAR, K. S., & RAO, B. P. (2023). Design, Synthesis, Characterization and Antibacterial Activity of Some Novel Furan Supported 1,2,4-Triazoles. Asian Journal of Chemistry, 35(10), 2493–2497. https://doi.org/10.14233/ajchem.2023.27959
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