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Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Copyright (c) 2023 S. SYED ALI FATHIMA, M. MOHAMED SAHUL MEERAN

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Synthesis, Characterization, DNA Synergy and Molecular Docking Studies of Novel 1,10-Phenanthroline Derived Mixed Ligand Metal(II) Complexes

https://doi.org/10.14233/ajchem.2023.28051
S. SYED ALI FATHIMA
International Research Centre, Department of Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil-626126, India
https://orcid.org/0000-0001-5240-6721
M. MOHAMED SAHUL MEERAN
SGS Gulf Limited-Jafza, Dubai, United Arab Emirates
https://orcid.org/0009-0000-4629-8576

Corresponding Author(s) : S. SYED ALI FATHIMA

syed.s@klu.ac.in

Asian Journal of Chemistry, Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Abstract

The effect of tumour and all its related costs, both human and commercial factor is driving the exploration for novel curative medicines.
Although platinum-based anticancer drugs have shown considerable success, their use is complicated by a number of drawbacks. Therefore, this study is mainly designed for transition metal complex based chemotherapeutic agents to reduce the obstacles for platinum-based anticancer agents presently used. Herein, novel mixed ligand-metal(II) complexes derived from 9-anthraldehyde, 2-aminophenol, metal chlorides and 1,10-phenanthroline (co-ligand) were synthesized and characterized using several spectral techniques, which revealed that they possess an octahedral structure. The interaction of calf thymus DNA (CT-DNA) with synthesized compounds confirmed that the compounds are binded with DNA via intercalation. The mode of interaction was affirmed by the docking simulations, where the synthesized compounds were docked with EGFR protein and 1B-DNA through intercalation. The biological screening results revealed that the synthesized complexes exhibited superior anti-pathogenic screening properties compared to ligands. The proliferation resistance against cancer cells and free radical scavenger studies of prepared compounds indicated that the presence of heterocyclic ligand is an important factor for boosting the anticancer potential and radical scavenger skill.

Keywords

Transition metal complex Octahedral geometry DNA synergy Anticancer potential
ALI FATHIMA, S. S., & SAHUL MEERAN, M. M. (2023). Synthesis, Characterization, DNA Synergy and Molecular Docking Studies of Novel 1,10-Phenanthroline Derived Mixed Ligand Metal(II) Complexes. Asian Journal of Chemistry, 35(10), 2336–2348. https://doi.org/10.14233/ajchem.2023.28051
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