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Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Copyright (c) 2023 SHRUTI VARSHNEY, ABHISHEK TIWARI, RAKHI MISHRA

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N-Heterocyclic Analogs: A New Prospect in Cancer Therapy

https://doi.org/10.14233/ajchem.2023.28156
SHRUTI VARSHNEY
Pharmacy Academy, IFTM University, Lodhipur-Rajput, Moradabad-244102, India 2. Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, India
https://orcid.org/0000-0001-9936-8128
ABHISHEK TIWARI
Pharmacy Academy, IFTM University, Lodhipur-Rajput, Moradabad-244102, India
https://orcid.org/0000-0003-1221-4754
RAKHI MISHRA
Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, India
https://orcid.org/0000-0002-9292-3448

Corresponding Author(s) : SHRUTI VARSHNEY

varshney08shruti@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Abstract

One of the serious problems in the healthcare industry is cancer. In today’s scenario, a lot of anticancer medications are available in the
market, but they are not specific for specific cancer or have poor safety value, adverse effects and high resistance. Therefore, the designing of safer and more focused anticancer medications is essential. In today’s situation, more than 85% of all medications with good physiological activity are heterocyclic compounds with one or more heteroatoms in the aromatic structure. The most common aromatic moieties that have the highest prevalence in anticancer medication are nitrogen-containing heterocycles. The information about the synthesis and anticancer activity of various N-containing derivatives, such as pyridine, pyrimidine, carbazole, indole, imidazole, benzimidazole, quinoline, isatin, pyrazole and triazole, has been summarized which directly indicates their anticancer potentiality against different types of cancer. The study also showed that in contrast to other substituents, the substitution of electron-withdrawing groups on the heterocyclic Ncontaining moiety has greater anticancer action. The information in this work might serve as a model for future investigations into the production and anticancer properties of novel N-containing heterocyclic compounds.

Keywords

Nitrogen-containing heterocycles Anticancer Biological activity MTT assay
VARSHNEY, S., TIWARI, A., & MISHRA, R. (2023). N-Heterocyclic Analogs: A New Prospect in Cancer Therapy. Asian Journal of Chemistry, 35(10), 2323–2335. https://doi.org/10.14233/ajchem.2023.28156
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