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Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Copyright (c) 2023 CHARISSE T. TUGAHAN

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Chemical Constituents of Macaranga grandifolia

https://doi.org/10.14233/ajchem.2023.28231
CHARISSE T. TUGAHAN
Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila 1004, Philippines
https://orcid.org/0009-0009-4161-8273
RHANNEY L. GONZALES
Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila 1004, Philippines Chemistry Department, Central Luzon State University, Science City of Munoz, Nueva Ecija 3120, Philippines
https://orcid.org/0000-0003-1615-0399
CHIEN-CHANG SHEN
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, 155-1, Li-Nong St., Sec. 2, Taipei 112, Taiwan
https://orcid.org/0000-0001-9106-0698
MARIA CARMEN S. TAN
Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila 1004, Philippines
https://orcid.org/0000-0003-4413-5460
CONSOLACION Y. RAGASA
Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila 1004, Philippines Chemistry Department, De La Salle University Science & Technology Complex Leandro V. Locsin Campus, Biñan City, Laguna 4024, Philippines
https://orcid.org/0000-0002-6687-6940

Corresponding Author(s) : CHARISSE T. TUGAHAN

charisse.tugahan@dlsu.edu.ph

Asian Journal of Chemistry, Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Abstract

The chemical analysis of dichloromethane (DCM) extract of Macaranga grandifolia (Blanco) Merr. resulted in the isolation and identification of several compounds. From the leaves, vedelianin (1), squalene (2), β-carotene (3) and polyprenol (4) were isolated. The barks contained a mixture of stigmasterol (5a) and β-sitosterol (5b). Additionally, the fruits yielded saturated fatty acid (6). The elucidation of structure 1 was accomplished through the utilization of comprehensive 1D and 2D NMR spectroscopic techniques. The identification of the structures of compounds 2-6 was achieved through a comparative analysis of their nuclear magnetic resonance (NMR) data with the literature data.

Keywords

Macaranga grandifolia (Blanco) Merr Vedelianin, Squalene β-Carotene Polyprenol Stigmasterol β-Sitosterol
TUGAHAN, C. T., GONZALES, R. L., SHEN, C.-C., S. TAN, M. C., & Y. RAGASA, C. (2023). Chemical Constituents of Macaranga grandifolia. Asian Journal of Chemistry, 35(9), 2230–2234. https://doi.org/10.14233/ajchem.2023.28231
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References
  1. T. Péresse, G. Jézéquel, P.M. Allard, V.C. Pham, D.T. Huong, F. Blanchard, J. Bignon, H. Lévaique, J.-L. Wolfender, M. Litaudon and F. Roussi, J. Nat. Prod., 80, 2684 (2017); https://doi.org/10.1021/acs.jnatprod.7b00409
  2. P.A. Segun, O.O. Ogbole, F.M. Ismail, L. Nahar, A.R. Evans, E.O. Ajaiyeoba and S.D. Sarker, Fitoterapia, 134, 151 (2019); htps://doi.org/10.1016/j.fitote.2019.02.019
  3. J.M. Joseph, J. Med. Plants Res., 8, 489 (2014); https://doi.org/10.5897/JMPR2014.5396
  4. L.T.N. Vu, T.B. Ngan, L.T. Phuong, D.T.M. Huong, M. Litaudon, N. Van Hung, T.D. Thach and P. Van Cuong, Vietnam J. Chem., 56, 516 (2018); https://doi.org/10.1002/vjch.201800040
  5. L.T.N. Vu, L.T. Anh, N.T. Cuc, N.X. Nhiem, B.H. Tai, P. Van Kiem and P. Van Cuong, Nat. Prod. Res., 35, 2123 (2019); https://doi.org/10.1080/14786419.2019.1662007
  6. D.T.M. Huong, N.T. Linh, T.T.T. Van, M. Litaudon, F. Roussi, V. Van Nam and P. Van Cuong, Vietnam J. Chem., 58, 338 (2020); https://doi.org/10.1002/vjch.2019000182
  7. Binunga Macaranga tanarius (Linn.) Muell.-Arg. Downloaded from www.stuartxchange.org/Binunga.html
  8. Binuñgang-malapad Macaranga grandifolia (Blanco) Merr. Downloaded from www.stuartxchange.org/Binungang-malapad.html
  9. E. Marliana, R. Ruga, R. Hairani, T.S. Tjahjandarie and M. Tanjung, J. Phys. Conf. Ser., 1277, 012014 (2019); https://doi.org/10.1088/1742-6596/1277/1/012014
  10. E. Marliana, R. Hairani, T.S. Tjahjandarie and M. Tanjung, IOP Conf. Ser. Earth Environ. Sci., 144, 012011 (2018); https://doi.org/10.1088/1755-1315/144/1/012011
  11. T.M.H. Doan, T.L. Nguyen, T.T.V. Trinh, V.N. Vu, T.D. Phi, M. Litaudon and V.C. Pham, J. Anal. Methods Chem., 2019, 2917032 (2019); https://doi.org/10.1155/2019/2917032
  12. P. Hendra, O.A. Jamil, D.A. Maharani, M.A. Suhadi, C.Y. Putri and J.J. Fenty, Asian J. Pharm. Clin. Res., 10, 239 (2017).
  13. M.D. Suba, A.H. Arriola, and G.J. D. Alejandro, Biodiversitas, 20, 1034 (2019).
  14. V.D. Ebajo Jr., R. Brkljaèa, S. Urban and R.Y. Ragasa, J. Appl. Pharm. Sci., 5, 69 (2015); https://doi.org/10.7324/JAPS.2015.501111
  15. C.Y. Ragasa, M.P. Medecilo and C.C. Shen, Der Pharm. Chem., 7, 395 (2015).
  16. V.D. Ebajo Jr., C.C. Shen and C.Y. Ragasa, Res. J. Appl. Pharm. Sci., 5, 33 (2015).
  17. C.Y. Ragasa, O.B. Torres, J.M.P. Gutierrez, H.P.B.C. Kristiansen and C.C. Shen, J. Appl. Pharm. Sci., 5, 94 (2015); https://doi.org/10.7324/JAPS.2015.50416
  18. O. Thoison, E. Hnawia, F. Guiéritte-Voegelein and T. Sévenet, Phytochemistry, 31, 1439 (1992); https://doi.org/10.1016/0031-9422(92)80315-6
  19. B.J. Yoder, S. Cao, A. Norris, J.S. Miller, F. Ratovoson, J. Razafitsalama, R. Andriantsiferana, V.E. Rasamison and D.G.I. Kingston, J. Nat. Prod., 70, 342 (2007); https://doi.org/10.1021/np060484y
  20. J.A. Beutler, R.H. Shoemaker, T. Johnson and M.R. Boyd, J. Nat. Prod., 61, 1509 (1998); https://doi.org/10.1021/np980208m
  21. J.J. Topczewski and D.F. Wiemer, Tetrahedron Lett., 52, 1628 (2011); https://doi.org/10.1016/j.tetlet.2011.01.137
  22. Z.R. Huang, Y.K. Lin and J.Y. Fang, Molecules, 14, 540 (2009); https://doi.org/10.3390/molecules14010540
  23. F.E. Günes, J. Marmara Univ. Institute Health Sci., 3, 1 (2013); https://doi.org/10.5455/musbed.20131213100404
  24. J.M. Lou-Bonafonte, R. Martínez-Beamonte, T. Sanclemente, J.C. Surra, L.V. Herrera-Marcos, J. Sanchez-Marco, C. Arnal and J. Osada, Mol. Nutr. Food Res., 62, 1800136 (2018); https://doi.org/10.1002/mnfr.201800136
  25. R. Cioncada, M. Maddaluno, H.T.M. Vo, M. Woodruff, S. Tavarini, C. Sammicheli, M. Tortoli, A. Pezzicoli, E. De Gregorio, M.C. Carroll, U. D’Oro and D. Piccioli, PLoS One, 12, e0185843 (2017); https://doi.org/10.1371/journal.pone.0185843
  26. J.M.C. Cayme and C.Y. Ragasa, Kimika, 20, 5 (2004); https://doi.org/10.26534/kimika.v20i1.5-12
  27. L. Bogacz-Radomska and J. Harasym, Food Qual. Saf., 2, 69 (2018); https://doi.org/10.1093/fqsafe/fyy004
  28. R. Tao, C. Wang, J. Ye, H. Zhou and H. Chen, BioMed Res. Int., 2016, 4191938 (2016); https://doi.org/10.1155/2016/4191938
  29. I. Vanaga, J. Gubernator, I. Nakurte, U. Kletnieks, R. Muceniece and B. Jansone, Molecules, 25, 1801 (2020); https://doi.org/10.3390/molecules25081801
  30. J. Hu, P. Li and T. Zhang, Phytother. Res., 32, 1450 (2018); https://doi.org/10.1002/ptr.6096
  31. X.X. Zhuang, X. Zang, G.Y. Zheng, N. Hua, Y. Sun, Y.H. Hu and L. He, Phytotherapy Res., 32, 1098 (2018).
  32. L. Yang, C. Wang, J. Ye and H. Li, Fitoterapia, 82, 834 (2011); https://doi.org/10.1016/j.fitote.2011.04.009
  33. H. Yuan, H. Shen, Y. Yan, C. Zhang and C. Wang, Chem. Ind. Forest Prod., 42, 5 (2022).
  34. H. Yuan, C. Zhang, P. Zhou, X. Yang, R. Tao, J. Ye and C. Wang, Arab. J. Chem., 16, 104679 (2023); https://doi.org/10.1016/j.arabjc.2023.104679
  35. M.M. Mailafiya, A.J. Yusuf, M.I. Abdullahi, G.A. Aleku, I.A. Ibrahim, M. Yahaya and C.O. Alebiosu, J. Med. Plants Econ. Dev., 2, 1 (2018); https://hdl.handle.net/10520/EJC-df2f206df
  36. N. Kaur, J. Chaudhary, A. Jain and L. Kishore, Int. J. Pharm. Sci. Res., 2, 2259 (2011).
  37. K. Rashed, J. Sci. Innov. Technol, 9, 208 (2020).
  38. A.A. Baskar, S. Ignacimuthu, G.M. Paulraj and K.S. Al Numair, BMC Complement. Altern. Med., 10, 24 (2010); https://doi.org/10.1186/1472-6882-10-24
  39. A.A. Baskar, K.S. Al Numair, M. Gabriel Paulraj, M.A. Alsaif, M.A. Muamar and S. Ignacimuthu, J. Med. Food, 15, 335 (2012); https://doi.org/10.1089/jmf.2011.1780
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