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Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Copyright (c) 2023 J UDAYA BHASKAR

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Design, Synthesis, Structural Characterization and Antimicrobial Screening of Several Novel Benzothiophene Linked Thiazolidines

https://doi.org/10.14233/ajchem.2023.27958
J UDAYA BHASKAR
School of Science, GITAM (Deemed to be University), Visakhapatnam-530045, India Dr. Reddy’s Laboratories Ltd., Srikakulam-532409, India
https://orcid.org/0009-0007-6963-8706
G. SRINIVASA RAO
School of Science, GITAM (Deemed to be University), Visakhapatnam-530045, India
https://orcid.org/0000-0001-9647-7206
B. PULLA RAO
Department of Chemistry, Acharya Nagarjuna University Nagarjuna Nagar, Guntur-522510, India
https://orcid.org/0009-0005-5965-0002
PRANAB CHATTERJEE
Dr. Reddy’s Laboratories Ltd., Srikakulam-532409, India
https://orcid.org/0009-0002-3848-6432
D.K. SAHOO
Dr. Reddy’s Laboratories Ltd., Srikakulam-532409, India
https://orcid.org/0009-0006-8697-7550
S. SRINIVASA RAO
Dr. Reddy’s Laboratories Ltd., Srikakulam-532409, India
https://orcid.org/0009-0001-1530-5072

Corresponding Author(s) : J UDAYA BHASKAR

judayabhaskar22@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Abstract

A novel sequence of (19E)-(3-(benzo[b]thiophen-3-yl)-N′-((Z)-5-benzyliden-4-oxo-3-phenyl thiazolidin-2-ylidene)propanehydrazides (6a-f) was synthesized in moderate to good yields from the final intermediate, (E)-(3-(benzo[b]thiophen-3-yl)-N′-(4-oxo-3-phenylthiazolidin- 2-ylidene)propane hydrazide (5). In present work, 3-(benzo[b]thiophen-3-yl)propanoic acid (1) was selected as raw material and  compounds such as 1-(benzo[b]thiophen-3-yl)pentan-3-one (2), 3-(benzo[b]thiophen-3-yl)propanehydrazide (3) and 1-(3-(benzo[b]- thiophen-3-yl)-propanoyl)-4-phenylsemicarbazide (4) were materialized as intermediates. All the isolated intermediates and target  compounds have been characterized with the data obtained from different spectroscopic methods. The products were also examined  against few microorganisms. According to the screening results, the tested targets performed satisfactory growth of inhibition. 

Keywords

Benzothiophene Thiazolidines Hybrid molecules Antimicrobial activity
BHASKAR, J. U., RAO, G. S., RAO, B. P., CHATTERJEE, P., SAHOO, D., & RAO, S. S. (2023). Design, Synthesis, Structural Characterization and Antimicrobial Screening of Several Novel Benzothiophene Linked Thiazolidines. Asian Journal of Chemistry, 35(9), 2176–2180. https://doi.org/10.14233/ajchem.2023.27958
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