Copyright (c) 2014 Gang Wang1, Yong Mei Xie2, Xing Hua Wang1
This work is licensed under a Creative Commons Attribution 4.0 International License.
Green Synthesis Improvement of Tenofovir Disoproxil
Corresponding Author(s) : Gang Wang1
Asian Journal of Chemistry,
Vol 26 No Supplementary Issue
Abstract
Polyethylene glycol, known as ‘Green Chemical’, is a catalyst for the synthesis of tenofovir disoproxil. Some technological parameters were discussed by adoptting via single-factor experiments. Through the catalytic reaction, not only tenofovir disoproxil yield was improved but also by-products was reduced obviously. The results showed that the optimal conditions were as follows: 0.6 equiv PEG-600, 4.0 equiv triethylamine, 6.0 equiv N-methyl-2-pyrrolidone and temperature at 50 °C for 16 h with a yield of 65.12 %.
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- K. Squires, A.L. Pozniak, G. Jr and Pierone, Ann. Intern. Med., 139, 313 (2003).
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References
K. Squires, A.L. Pozniak, G. Jr and Pierone, Ann. Intern. Med., 139, 313 (2003).
R.T. Schooley, P. Ruane, R.A. Myers, G. Beall, H. Lampiris, D. Berger, S.-S. Chen, M.D. Miller, E. Isaacson and A.K. Cheng, AIDS, 16, 1257 (2002).
S.R. Houghton, J. Melton, J. Fortunak, D.H. Brown Ripin and C.N. Boddy, Tetrahedron, 66, 8137 (2010).
M.A. Shuai, W. Wei, J-Y. Jia and S.-H. Cao, Chinese J. Med. Chem., 23, 372 (2013).
C.-L. Yu, H.R. Wen and J.C. Yu, Nanotechnol. Precision Eng., 8, 161 (2010).
C.-Y. Zheng, J.-S Hu, S.-Y. Yu and Y.-J. Shang, J. Anhui Normal Univ., 34, 244 (2011).
D.H. Brown Ripin, D.S. Teager, J. Fortunak, S.M. Basha, N. Bivins, C.N. Boddy, S. Byrn, K.K. Catlin, S.R. Houghton, S.T. Jagadeesh, K.A. Kumar, J. Melton, S. Muneer, L.N. Rao, R.V. Rao, P.C. Ray, N.G. Reddy, R.M. Reddy, K.C. Shekar, T. Silverton, D.T. Smith, R.W. Stringham, G.V. Subbaraju, F. Talley and A. Williams, Org. Process Res. Dev., 14, 1194 (2010).