Copyright (c) 2014 Ambreen Ghani*, Erum A. Hussain, Abida Yasmeen, Narjis Naz, Shaheen Asghar
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis of Novel 2,4-Disubstituted Bioactive Thiazoles
Corresponding Author(s) : Ambreen Ghani*
Asian Journal of Chemistry,
Vol 26 No Supplementary Issue
Abstract
A series of 2,4-disubstituted thiazoles was synthesized by iodine mediated method in good to excellent yield. All the novel compounds were evaluated for in vitro anti-mutagenic activity, revealing synergistic results. The structures of all new fabricated compounds were characterized by FTIR, UV and MS techniques.
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- D. Kumar, N. Maruthi Kumar, K.-H. Chang and K. Shah, Eur. J. Med. Chem., 45, 4664 (2010).
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- G. Evindar and R.A. Batey, J. Org. Chem., 71, 1802 (2006).
- D.S. Bose and M. Idrees, J. Org. Chem., 71, 8261 (2006).
- R. Wang, W.-J. Yang, L. Yue, W. Pan and H.-Y. Zeng, Synlett, 23, 1643 (2012).
- N.R. Ferrigni, J.E. Putnam, B. Anderson, L.B. Jacobsen, D.E. Nichols, D.S. Moore, J.L. McLaughlin, R.G. Powell and C.R. Smith, J. Nat. Prod., 45, 679 (1982).
- R. Revathi, P.R. Venkatesha, S.S. Saravanabhavan, C. Rajesh, V.R. Sangeetha, G.R. Selva and V. Alagarsamy, J. Pharm. Res., 4, 3566 (2011).
- A. Kryshchyshyn, Sci. Pharm., 80, 509 (2012).
- M. Ghorab and M.S. Al-Said, Arch. Pharm. Res., 35, 965 (2012).
- P. Joubert, D. Beaupère, P. Lelièvre, A. Wadouachi, R.S. Sangwan and B.S. Sangwan-Norreel, Plant Sci., 162, 733 (2002).
- N.A.M.M. Shmeiss, M.M.F. Ismail, A.M. Soliman and H.I. El-Diwani, Molecules, 5, 1101 (2000).
References
D. Kumar, N. Maruthi Kumar, K.-H. Chang and K. Shah, Eur. J. Med. Chem., 45, 4664 (2010).
A. Satish, R. Punith Kumar, D. Rakshith, S. Satish and F. Ahmed, Int. J. Chem. Anal. Sci., 4, 45 (2013).
S. Bhattachar, Res. J. Med. Plant., 5, 116 (2011).
S. De Flora and C. Ramel, Mutat. Res., 202, 285 (1988).
J.R. Lewis, J.R. Lewis and J.R. Lewis, Nat. Prod. Rep., 16, 389 (1999).
F. Clemence, O. Le Martret, F. Delevallee, J. Benzoni, A. Jouanen, S. Jouquey, M. Mouren and R. Deraedt, J. Med. Chem., 31, 1453 (1988).
R. Lesyk, O. Vladzimirska, S. Holota, L. Zaprutko and A. Gzella, Eur. J. Med. Chem., 42, 641 (2007).
K. Tsuji and H. Ishikawa, Bioorg. Med. Chem. Lett., 4, 1601 (1994).
F.W. Bell, A.S. Cantrell, M. Hoegberg, S.R. Jaskunas, N.G. Johansson, C.L. Jordan, M.D. Kinnick, P. Lind and J.M. Morin, J. Med. Chem., 38, 4929 (1995).
W.C. Patt, H.W. Hamilton, M.D. Taylor, M.J. Ryan, D.G. Taylor, C.J.C. Connolly, A.M. Doherty, S.R. Klutchko and I. Sircar, J. Med. Chem., 35, 2562 (1992).
J.V. Metzger, Comprehensive Heterocyclic Chemistry, Pergamon Press, vol. 6, p. 328 (1984).
M.T. Shreenivas, B.E. Kumara Swamy, G.R. Srinivasa and B.S. Sherigara, Der Pharma Chemica, 3, 156 (2011).
J. Roger, F. Požgan and H. Doucet, J. Org. Chem., 74, 1179 (2009).
G. Evindar and R.A. Batey, J. Org. Chem., 71, 1802 (2006).
D.S. Bose and M. Idrees, J. Org. Chem., 71, 8261 (2006).
R. Wang, W.-J. Yang, L. Yue, W. Pan and H.-Y. Zeng, Synlett, 23, 1643 (2012).
N.R. Ferrigni, J.E. Putnam, B. Anderson, L.B. Jacobsen, D.E. Nichols, D.S. Moore, J.L. McLaughlin, R.G. Powell and C.R. Smith, J. Nat. Prod., 45, 679 (1982).
R. Revathi, P.R. Venkatesha, S.S. Saravanabhavan, C. Rajesh, V.R. Sangeetha, G.R. Selva and V. Alagarsamy, J. Pharm. Res., 4, 3566 (2011).
A. Kryshchyshyn, Sci. Pharm., 80, 509 (2012).
M. Ghorab and M.S. Al-Said, Arch. Pharm. Res., 35, 965 (2012).
P. Joubert, D. Beaupère, P. Lelièvre, A. Wadouachi, R.S. Sangwan and B.S. Sangwan-Norreel, Plant Sci., 162, 733 (2002).
N.A.M.M. Shmeiss, M.M.F. Ismail, A.M. Soliman and H.I. El-Diwani, Molecules, 5, 1101 (2000).