Copyright (c) 2014 Rashida Parveen1, Naveed Akhtar1, Muhammad Abid1, Imran Shair Mohammad1
This work is licensed under a Creative Commons Attribution 4.0 International License.
Microemulsion Containing Ellagic Acid Rich Extract and Its Characterization
Corresponding Author(s) : Rashida Parveen1
Asian Journal of Chemistry,
Vol 26 No Supplementary Issue
Abstract
Ellagic acid, the active component in Punica granatum extract, has been reported to have the antioxidant, anti-tyrosinase and ultra-violet induced pigmentation in the human skin effects. In this study, extract was obtained from the Punica granatum fruit rinds which were extracted by 50 % ethanol and analyzed ellagic acid by UV method at 365 nm. The percentage of ellagic acid is about 84.48 %. Microemulsions were formulated using pseudoternary phase diagram. Palm oil and water were chosen as the oil and aqueous phase, respectively. The surfactant (Tween 80) and co-surfactant (PG) were used in preparation of the microemulsion. They were mixed in different ratios (2:1 and 5:1). The results showed the region of microemulsion on the phase diagram was obtained when increase the ratio of Tween 80. Evaluation of microemulsion regarding particle size, zeta potential, conductivity, stability, viscosity, scanning electron microscopy, refractive index and pH. This study established that a stable ellagic acid rich extract containing microemulsion was used for further topical uses.
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- A.P. Kulkarni and S.M. Aradhya, Food Chem., 93, 319 (2005).
- M. Maskan, J. Food Eng., 72, 218 (2006).
- D. Syed, F. Afaq and H. Mukhtar, Semin. Cancer Biol., 17, 377 (2007).
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- P.S. Navindra, M.H. Susanne, Z. Yanjun, S. Marc, L. Zhaoping and H. David, J. Nutr., 136, 2481 (2006).
- S.B. Leslie, Dermatol. Ther., 20, 30 (2007).
- M. Yoshimura, Y. Watanabe, K. Kasai, J. Yamakoshi and T. Koga, Biosci. Biotechnol. Biochem., 69, 2368 (2005).
- M.J. Periago, F. Rincón, M.D. Agüera and G. Ros, J. Agric. Food Chem., 52, 5796 (2004).
- J.D. Sadler and D. Dezman, J. Food Sci., 55, 1460 (2006).
- P. Katakam and C. Narendra, Asian J. Pharmacy Life Sci., 1, 354 (2011).
- J.D. Modi and J.K. Patel, Int. J. Pharm. Pharm. Sci. Res., 1, 6 (2011).
- H. Lambers, S. Piessens, A. Bloem, H. Pronk and P. Finkel, Int. J. Cosmet. Sci., 28, 359 (2006).
- K. Jadhav, S. Shetye and V. Kadam, Int. J. Adv. Pharm. Sci., 1, 156 (2011).
References
A.P. Kulkarni and S.M. Aradhya, Food Chem., 93, 319 (2005).
M. Maskan, J. Food Eng., 72, 218 (2006).
D. Syed, F. Afaq and H. Mukhtar, Semin. Cancer Biol., 17, 377 (2007).
A. Michael, D. Leslie, R. Mira, V. Nina, K. Marielle, C. Raymond, H. Tony, P. Dita and F. Bianca, Am. J. Clin. Nutr., 71, 1062 (2000).
M.N. Aslam, E.P. Lansky and J. Varani, J. Ethnopharmacol., 103, 311 (2006).
P.S. Navindra, M.H. Susanne, Z. Yanjun, S. Marc, L. Zhaoping and H. David, J. Nutr., 136, 2481 (2006).
S.B. Leslie, Dermatol. Ther., 20, 30 (2007).
M. Yoshimura, Y. Watanabe, K. Kasai, J. Yamakoshi and T. Koga, Biosci. Biotechnol. Biochem., 69, 2368 (2005).
M.J. Periago, F. Rincón, M.D. Agüera and G. Ros, J. Agric. Food Chem., 52, 5796 (2004).
J.D. Sadler and D. Dezman, J. Food Sci., 55, 1460 (2006).
P. Katakam and C. Narendra, Asian J. Pharmacy Life Sci., 1, 354 (2011).
J.D. Modi and J.K. Patel, Int. J. Pharm. Pharm. Sci. Res., 1, 6 (2011).
H. Lambers, S. Piessens, A. Bloem, H. Pronk and P. Finkel, Int. J. Cosmet. Sci., 28, 359 (2006).
K. Jadhav, S. Shetye and V. Kadam, Int. J. Adv. Pharm. Sci., 1, 156 (2011).