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Vol. 29 No. 9 (2017): Vol 29 Issue 9

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Industrially Scalable Synthesis of Anti-alzheimer Drug Donepezil

https://doi.org/10.14233/ajchem.2017.20716
Santosh L. Gaonkar
Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal-576 104, India
Y.F. Nadaf
Department of Physics and Research Center, Maharani Science College for Womens, Bangalore-560 001, India
Dinesh Bilehal
Department of Chemistry, Reva University, Bangalore-560 064, India
Nitinkumar S. Shetty
Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal-576 104, India

Corresponding Author(s) : Santosh L. Gaonkar

gaonkarslg@rediffmail.com

Asian Journal of Chemistry, Vol. 29 No. 9 (2017): Vol 29 Issue 9

Abstract

This paper describes a simple, efficient and industrially scalable total synthesis of donepezil hydrochloride. The article also reported the X-ray studies of the 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyindan-1-one, an intermediate in the synthesis of donepezil. The crystal structure analysis of 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyindan-1-one shows that it crystallizes in monoclinic class under the space group P121/c1 with cell parameters, a = 17.2992(7) Å, b = 10.1999(4) Å, c = 11.9539(5) Å, b = 103.450(2)°, V = 2051.42(15) Å3 and Z = 4.

Keywords

Donepezil Alzheimer’s disease X-ray diffraction
Gaonkar, S. L., Nadaf, Y., Bilehal, D., & Shetty, N. S. (2017). Industrially Scalable Synthesis of Anti-alzheimer Drug Donepezil. Asian Journal of Chemistry, 29(9), 1999–2004. https://doi.org/10.14233/ajchem.2017.20716
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