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Vol. 29 No. 8 (2017): Vol 29 Issue 8

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Complex Formation Reactions of Palladium(II) and Amlodipine Drug with Biologically Active Ligands

https://doi.org/10.14233/ajchem.2017.20496
Salhah D. Al-Qahtani
Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
Reda A. Ammar
Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia; Deanship of Scientific Research, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
Lamina A. Al-Bedair
Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
Azaa F. Alshalawi
Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

Corresponding Author(s) : Reda A. Ammar

raammar@pnu.edu.sa

Asian Journal of Chemistry, Vol. 29 No. 8 (2017): Vol 29 Issue 8

Abstract

The stability constants of various complexes of [Pd(drug)(H2O)2]2+ (drug = amlodipine) with peptides, (L) viz. glycylglycine, leucylalanine, glycylvaline, glycinamide and glutamine have been studied using potentiometric measurements. The complexes formation procedure has been predictable according to the pH range studied. A different complexes constants were determined under 0.1 mol/dm3 NaNO3 and 25 °C conditions such as stability and stoichiometries constants.

Keywords

Drug Potentiometric studies Solution equilibria Stability constants Peptides
Al-Qahtani, S. D., Ammar, R. A., Al-Bedair, L. A., & Alshalawi, A. F. (2017). Complex Formation Reactions of Palladium(II) and Amlodipine Drug with Biologically Active Ligands. Asian Journal of Chemistry, 29(8), 1669–1672. https://doi.org/10.14233/ajchem.2017.20496
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