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Vol. 29 No. 6 (2017): Vol 29 Issue 6

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Silica Catalyst Promoted One-Pot Synthesis of 4-[(Dialkylamino)methyl]-1,7-diphenylhepta-1,6-diene-3,5-dione

https://doi.org/10.14233/ajchem.2017.20447
Mahesh G. Shioorkar
Department of Chemistry, Vivekanand Arts, S.D. Commerce and Science College, Aurangabad-431 001, India
Milind B. Ubale
Department of Chemistry, Vasantrao Naik College, Aurangabad-431 001, India

Corresponding Author(s) : Milind B. Ubale

mbubale@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 6 (2017): Vol 29 Issue 6

Abstract

Silica (SiO2) catalyzed one-pot synthesis of 4-[(dialkylamino)methyl]-1,7-diphenylhepta-1,6-diene-3,5-dione. An expeditious synthesis under microwave irradiation method for curcumin Mannich base derivatives are known for its biological activity. Curcumin is naturally occurring yellow pigments isolated from Curcuma longa, structurally it is polyphenolic compounds consisting spectacular biological activity. However, clinical utility of curcumin is limited due to its poor bioavailability. Present methodology offers silica catalyzed one pot, productive technique to obtain curcumin Mannich base. Both, conventional and microwave irradiation methods were found productive. The final products were characterized by 1H NMR.

Keywords

Curcumin Mannich reaction One-pot Conventional and Microwave irradiation method
Shioorkar, M. G., & Ubale, M. B. (2017). Silica Catalyst Promoted One-Pot Synthesis of 4-[(Dialkylamino)methyl]-1,7-diphenylhepta-1,6-diene-3,5-dione. Asian Journal of Chemistry, 29(6), 1249–1252. https://doi.org/10.14233/ajchem.2017.20447
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