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Synthesis, Characterization and Biological Applications of Pyrazole-Benzothiazolamine Conjugates
Corresponding Author(s) : Ramayanam S.K. Sharma
Asian Journal of Chemistry,
Vol. 29 No. 5 (2017): Vol 29 Issue 5
Abstract
Present paper describes the synthesis of some new pyrazole-benzothiazolamine conjugates by molecular conjunction by adopting appropriate synthetic routes. Purification of intermediates and final compounds has been done by recrystallization and chromatographic techniques. Characterization of all the newly synthesized pyrazole-benzothiazolamine derivatives was done by physical and spectral data. The experimental procedure for the preparation of seventeen pyrazole-benzthiazolamine conjugates has been incorporated. Data of synthesized compounds like IR, 1H NMR and Mass spectra were neatly presented. All these compounds were evaluated for their activity against Gram-positive and Gram-negative bacteria and various fungal strains. Anticancer activity has been carried out for the synthesized compounds using HeLa, DU145 and A549 cell lines using MTT assay and we found that the pyrazole-benzothiazolamine conjugates were possess antimicrobial, antifungal and anticancer activities.
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- Z. Wang, X.-H. Shi, J. Wang, T. Zhou, Y.-Z. Xu, T.-T. Huang, Y.-F. Li, Y.-L. Zhao, L. Yang, S.-Y. Yang, L.-T. Yu and Y.-Q. Wei, Bioorg. Med. Chem. Lett., 21, 1097 (2011); https://doi.org/10.1016/j.bmcl.2010.12.124.
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References
Z. Wang, X.-H. Shi, J. Wang, T. Zhou, Y.-Z. Xu, T.-T. Huang, Y.-F. Li, Y.-L. Zhao, L. Yang, S.-Y. Yang, L.-T. Yu and Y.-Q. Wei, Bioorg. Med. Chem. Lett., 21, 1097 (2011); https://doi.org/10.1016/j.bmcl.2010.12.124.
L. Jin, B. Song, G. Zhang, R. Xu, S. Zhang, X. Gao, D. Hu and S. Yang, Bioorg. Med. Chem. Lett., 16, 1537 (2006); https://doi.org/10.1016/j.bmcl.2005.12.041.
D. Havrylyuk, L. Mosula, B. Zimenkovsky, O. Vasylenko, A. Gzella and R. Lesyk, Eur. J. Med. Chem., 45, 5012 (2010); https://doi.org/10.1016/j.ejmech.2010.08.008.
C.G. Mortimer, G. Wells, J.-P. Crochard, E.L. Stone, T.D. Bradshaw, M.F.G. Stevens and A.D. Westwell, J. Med. Chem., 49, 179 (2006); https://doi.org/10.1021/jm050942k.
M. Amir, S.A. Javed and M. Zaheen Hassan, Med. Chem. Res., 21, 1261 (2012); https://doi.org/10.1007/s00044-011-9642-0.
B.S. Soni, M. Ranawat, R. Sharma, A. Bhandari and S. Sharma, Eur. J. Med. Chem., 45, 2938 (2010); https://doi.org/10.1016/j.ejmech.2010.03.019.
D.Chauhan, A.A. Siddiqui, K.Rajakumari and R. Singh, Int. J. Chem. Sci., 7, 316 (2015).
N. Siva Subramanian, G. Omprakash, Y. Anjaneyulu, V.R.M. Gupta and M. Ramadevi, Int. J. Chem. Sci., 7, 1537 (2009).
S.T. Asundaria and K.C. Patel, Pharm. Chem. Lett., 45, 725 (2012); https://doi.org/10.1007/s11094-012-0712-5.
P. Jimonet, F. Audiau, M. Barreau, J.-C. Blanchard, A. Boireau, Y. Bour, M.-A. Coléno, A. Doble, G. Doerflinger, C. Do Huu, M.-H. Donat, J.M. Duchesne, P. Ganil, C. Guérémy, E. Honoré, B. Just, R. Kerphirique, S. Gontier, P. Hubert, P.M. Laduron, J. Le Blevec, M. Meunier, J.-M. Miquet, C. Nemecek, M. Pasquet, O. Piot, J. Pratt, J. Rataud, M. Reibaud, J.-M. Stutzmann and S. Mignani, J. Med. Chem., 42, 2828 (1999); https://doi.org/10.1021/jm980202u.
F. Delmas, A. Avellaneda, C. Di Giorgio, M. Robin, E. De Clercq, P. Timon-David and J.-P. Galy, J. Med. Chem., 39, 685 (2004); https://doi.org/10.1016/j.ejmech.2004.04.006.
A. Kamal, K.S. Reddy, M.N. Khan, R.V.C.R.N.C. Shetti, M.J. Ramaiah, S.N.C.V.L. Pushpavalli, C. Srinivas, M. Pal-Bhadra, M. Chourasia, G.N. Sastry, A. Juvekar, S. Zingde and M. Barkume, Bioorg. Med. Chem., 18, 4747 (2010); https://doi.org/10.1016/j.bmc.2010.05.007.
V.S. Patil, K.P. Nandre, S. Ghosh, V.J. Rao, B.A. Chopade, B. Sridhar, S.V. Bhosale and S.V. Bhosale, Eur. J. Med. Chem., 59, 304 (2013); https://doi.org/10.1016/j.ejmech.2012.11.020.
S.R. Nagarajan, G.A. De Crescenzo, D.P. Getman, H.-F. Lu, J.A. Sikorski, J.L. Walker, J.J. McDonald, K.A. Houseman, G.P. Kocan, N. Kishore, P.P. Mehta, C.L. Funkes-Shippy and L. Blystone, Bioorg. Med. Chem., 11, 4769 (2003); https://doi.org/10.1016/j.bmc.2003.07.001