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Vol. 29 No. 2 (2017): Vol 29 Issue 2

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Green Synthesis and Characterization of 3-Carboxycoumarin and Ethylcoumarin-3-carboxylate via Knoevenagel Condensation

https://doi.org/10.14233/ajchem.2017.20142
Syed Salman Shafqat
Department of Mechanical and Manufacturing Engineering, Faculty of Engineering, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
Amir Azam Khan
Department of Mechanical and Manufacturing Engineering, Faculty of Engineering, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
Misbahul Ain Khan
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Shanti Faridah Salleh
Department of Chemical Engineering and Energy Sustainability, Faculty of Engineering, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
Mohd Syahmi Jamaludin
Department of Mechanical and Manufacturing Engineering, Faculty of Engineering, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
Pang Suh Cem
Department of Chemistry, Faculty of Resource Science &Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

Corresponding Author(s) : Amir Azam Khan

akamir@unimas.my

Asian Journal of Chemistry, Vol. 29 No. 2 (2017): Vol 29 Issue 2

Abstract

Environmentally benign, simple, efficient and clean syntheses of 3-carboxycoumarins and ethyl coumarin-3-carboxylate have been synthesized via Knoevenagel condensation using green catalysts such as aqueous extract of Acacia concinna pods and amino acids. These syntheses were carried out in solvents as well as solvent-less media. The yields obtained (between 86 % to 96 %) for the reactions were equal or better than those previously reported. The products were isolated, purified and characterized through melting points, TLC, IR, GC Mass and 1H NMR spectroscopy. The characterized molecules showed structural and compositional conformity with the predicted reactions. The green route used for these reactions has shown to be efficient in reducing the time of reaction and in avoiding the toxic nature of the catalysts employed in classical reaction.

Keywords

Green protocol Acacia concinna Amino acids 3-Carboxycoumarins Knoevenagel condensation
Shafqat, S. S., Khan, A. A., Khan, M. A., Salleh, S. F., Jamaludin, M. S., & Cem, P. S. (2016). Green Synthesis and Characterization of 3-Carboxycoumarin and Ethylcoumarin-3-carboxylate via Knoevenagel Condensation. Asian Journal of Chemistry, 29(2), 261–266. https://doi.org/10.14233/ajchem.2017.20142
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