Copyright (c) 2017 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis and Antibacterial Study of Eugenol Derivatives
Asian Journal of Chemistry,
Vol. 29 No. 1 (2017): Vol 29 Issue 1
Abstract
A series of eugenol derivatives (2-14) were synthesized and evaluated for their antibacterial activity against five bacterial test strains; three Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis) and two Gram-negative bacteria (Escherichia coli and Salmonella typhimurium) using well-diffusion method. Among the compounds tested, compounds 2-4 displayed susceptible activity toward S. epidermidis with 16-18 mm whereas compounds 12 exhibited susceptible inhibition towards S. aureus only with inhibition diameter of 16 mm, respectively. Other compounds possessed varied antibacterial activities classified as intermediate or resistance indicating that eugenol derivatives have narrow spectrum activity and specifically to Gram-positive bacteria.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- F.M. Abdel Bar, M.A. Khanfar, A.Y. Elnagar, F.A. Badria, A.M. Zaghloul, K.F. Ahmad, P.W. Sylvester and K.A. El Sayed, Bioorg. Med. Chem., 18, 496 (2010).
- H. Carrasco A, L. Espinoza C, V. Cardile, C. Gallardo, W. Cardona, L. Lombardo, K. Catalán M, M. Cuellar F and A. Russo, J. Braz. Chem. Soc., 19, 543 (2008).
- M.E. Hidalgo, C. De la Rosa, H. Carrasco, W. Cardona, C. Gallardo and L. Espinoza, Quim. Nova, 32, 1467 (2009).
- K.G. Lee and T. Shibamoto, Food Chem., 74, 443 (2001).
- S.E. Moon, H.Y. Kim and J.D. Cha, Arch. Oral Biol., 56, 907 (2011).
- Y. Huang, S.H. Ho, H.C. Lee and Y.L. Yap, J. Stored Prod. Res., 38, 403 (2002).
- W.R. Hume, J. Dent. Res., 62, 1013 (1983).
- K. Markowitz, M. Moynihan, M. Liu and S. Kim, Oral Surg. Oral Med. Oral Pathol., 73, 729 (1992).
- L. Jirovetz, G. Buchbauer, I. Stoilova, A. Stoyanova, A. Krastanov and E. Schmidt, J. Agric. Food Chem., 54, 6303 (2006).
- H. Wagner, K. Jurcic and R. Deininger, Planta Med., 37, 9 (1979).
- J. Feng and J.M. Lipton, Neuropharmacology, 26, 1775 (1987).
- M.I. Nassar, A.H. Gaara, A.H. El-Ghorab, A.R.H. Farrag, H. Shen, E. Huq and T.J. Mabry, Rev. Latinoamer. Quim., 35, 47 (2007).
- A. Alqareer, A. Alyahya and L. Andersson, J. Dent., 34, 747 (2006).
- D. Rico-Molina, G. Aparicio-Ozores, L. Dorantes-Alvarez and H. Hernandez-Sanchez, Am. J. Food Technol., 7, 289 (2012).
- K.P. Devi, S.A. Nisha, R. Sakthivel and S.K. Pandian, J. Ethnopharmacol., 130, 107 (2010).
References
F.M. Abdel Bar, M.A. Khanfar, A.Y. Elnagar, F.A. Badria, A.M. Zaghloul, K.F. Ahmad, P.W. Sylvester and K.A. El Sayed, Bioorg. Med. Chem., 18, 496 (2010).
H. Carrasco A, L. Espinoza C, V. Cardile, C. Gallardo, W. Cardona, L. Lombardo, K. Catalán M, M. Cuellar F and A. Russo, J. Braz. Chem. Soc., 19, 543 (2008).
M.E. Hidalgo, C. De la Rosa, H. Carrasco, W. Cardona, C. Gallardo and L. Espinoza, Quim. Nova, 32, 1467 (2009).
K.G. Lee and T. Shibamoto, Food Chem., 74, 443 (2001).
S.E. Moon, H.Y. Kim and J.D. Cha, Arch. Oral Biol., 56, 907 (2011).
Y. Huang, S.H. Ho, H.C. Lee and Y.L. Yap, J. Stored Prod. Res., 38, 403 (2002).
W.R. Hume, J. Dent. Res., 62, 1013 (1983).
K. Markowitz, M. Moynihan, M. Liu and S. Kim, Oral Surg. Oral Med. Oral Pathol., 73, 729 (1992).
L. Jirovetz, G. Buchbauer, I. Stoilova, A. Stoyanova, A. Krastanov and E. Schmidt, J. Agric. Food Chem., 54, 6303 (2006).
H. Wagner, K. Jurcic and R. Deininger, Planta Med., 37, 9 (1979).
J. Feng and J.M. Lipton, Neuropharmacology, 26, 1775 (1987).
M.I. Nassar, A.H. Gaara, A.H. El-Ghorab, A.R.H. Farrag, H. Shen, E. Huq and T.J. Mabry, Rev. Latinoamer. Quim., 35, 47 (2007).
A. Alqareer, A. Alyahya and L. Andersson, J. Dent., 34, 747 (2006).
D. Rico-Molina, G. Aparicio-Ozores, L. Dorantes-Alvarez and H. Hernandez-Sanchez, Am. J. Food Technol., 7, 289 (2012).
K.P. Devi, S.A. Nisha, R. Sakthivel and S.K. Pandian, J. Ethnopharmacol., 130, 107 (2010).