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Vol. 29 No. 12 (2017): Vol 29 Issue 12

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Synthesis and Antimicrobial Evaluation of Some New Thiazolo Imidazole Analogs

https://doi.org/10.14233/ajchem.2017.20738
S. Ramamurthy
Department of Pharmaceutical Chemistry, Visveswarapura Institute of Pharmaceutical Sciences, B.S.K II Stage, Bangalore-560 070, India
E. Jayachandran
S.C.S. College of Pharmacy, Harapanahalli-583 131, India

Corresponding Author(s) : S. Ramamurthy

ramamurthyronisha@yahoo.com; ramamurthyvips@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 12 (2017): Vol 29 Issue 12

Abstract

Thiazole and imidazole derivatives have attracted medicinal chemists owing to their extensive biological activities. Present paper describes the synthesis of some new thiazolo imidazole derivatives. 4-Substituted phenacyl bromides were prepared from substituted acetophenones. The products were condensed with thiourea to obtain 2-amino-4-(4-substituted phenyl)thiazoles which on further reaction with 4-substituted phenacyl bromides resulted in 3,6-di(substituted phenyl)imidazo[2,1-b] thiazoles (3a-3i). The formation of all the compounds was established by spectral techniques like IR, 1H NMR and Mass spectral data. The title compounds were screened for their antimicrobial activity against Gram-positive bacteria S. aureus and B. subtilis, Gram-negative bacteria E. coli and K. pneumoniae and the fungal strains like A. niger, C. albicans and C. neoformans. The results indicated that the compounds coded 3a, 3c, 3g and 3i showed significant activity than the remaining compounds.

Keywords

Thiazole Imidazoles Synthesis Antibacterial Antifungal
Ramamurthy, S., & Jayachandran, E. (2017). Synthesis and Antimicrobial Evaluation of Some New Thiazolo Imidazole Analogs. Asian Journal of Chemistry, 29(12), 2639–2642. https://doi.org/10.14233/ajchem.2017.20738
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