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Synthesis and in vitro Study of Novel Thiophenyl Benzoimidazolyl Benzamides, Acrylamides and Propionamides as Antimicrobial Agents
Corresponding Author(s) : Ravi Chandra Babu
Asian Journal of Chemistry,
Vol. 29 No. 10 (2017): Vol 29 Issue 10
Abstract
A series of novel 2/3 (1H-benzo[d]imidazol-2-yl)-N-(4-benzolyl-5-ethylthiophene-2-yl)benzamides, acrylamides and propionamides have been synthesized and the antimicrobial activities are evaluated against two Gram-positive and two Gram-negative bacteria and two plant-pathogenic fungi. Some of the synthesized compounds have showed superior in vitro activities as compared to the standard drugs. The chemical structures of all these compounds are identified by IR, 1H NMR, mass spectroscopy and elemental analysis.
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References
P.N. Preston, Chem. Rev., 74, 279 (1974); https://doi.org/10.1021/cr60289a001.
R. Cedillo-Rivera and O. Munoz, J. Med. Microbiol., 37, 221 (1992); https://doi.org/10.1099/00222615-37-3-221.
B. Chavez, R. Cedillo-Rivera and A. Martinez-Palomo, J. Protozool., 39, 510 (1992); https://doi.org/10.1111/j.1550-7408.1992.tb04841.x.
G. Navarrete-Vázquez, R. Cedillo, A. Hernández-Campos, L. Yépez, F. Hernández-Luis, J. Valdez, R. Morales, R. Cortés, M. Hernández and R. Castillo, Bioorg. Med. Chem. Lett., 11, 187 (2001); https://doi.org/10.1016/S0960-894X(00)00619-3.
H. Yun, J. Yang, B. Wu, L. Risen and E.E. Swayze, Bioorg. Med. Chem. Lett., 14, 1217 (2004); https://doi.org/10.1016/j.bmcl.2003.12.051.
M.A. Weidner-Wells, K.A. Ohemeng, V.N. Nguyen, S. Fraga-Spano, M.J. Macielag, H.M. Werblood, B.D. Foleno, G.C. Webb, J.F. Barrett and D.J. Hlasta, Bioorg. Med. Chem. Lett., 11, 1545 (2001); https://doi.org/10.1016/S0960-894X(01)00024-5.
P.P. Seth, E.A. Jefferson, L.M. Risen and S.A. Osgood, Bioorg. Med. Chem. Lett., 13, 1669 (2003); https://doi.org/10.1016/S0960-894X(03)00245-2.
M. Nakanishi, T. Tahara, K. Araki, M. Shiroki, T. Tsumagari and Y. Takigawa, J. Med. Chem., 16, 214 (1973); https://doi.org/10.1021/jm00261a010.
S. Tinney, J.P. Sanchez and J.A. Nogas, J. Med. Chem., 17, 624 (1974); https://doi.org/10.1021/jm00252a011.
H. Nagaoka, H. Hara and T. Mase, Heterocycles, 31, 1241 (1990); https://doi.org/10.3987/COM-90-5442.
P.A.M. van der Klein, A.P. Kourounakis and A.P. IJzerman, J. Med. Chem., 42, 3629 (1999); https://doi.org/10.1021/jm991051d.
J.C. Vincent, H.N. Vincent and J. Morton, Proc. Soc. Exp. Biol. Med., 55, 162 (1944); https://doi.org/10.3181/00379727-55-14502.
E.H. Allen and J. Kuc, Phytopathology, 58, 776 (1968).