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Vol. 26 No. 24 (2014)

Copyright (c) 2014 Y.N. Mabkhot1, N.N.E. El-Sayed1, F. Alatibi1, A. Barakat1, H.A. Ghabbour3, H-K. Fun3

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization and X-Ray Crystal Structure of 3-Methyl-4-oxo-7-phenyl-4,7-dihydrothieno[2,3-b]pyridine-2-carboxyxlic Acid Ethyl Ester

https://doi.org/10.14233/ajchem.2014.18416
Y.N. Mabkhot1
1Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt 3Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia 4X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800, Malaysia *Corresponding authors: Fax: +966 14675992; Tel: +966 14675898; E-mail: yahia@ksu.edu.sa; ambarakat@ksu.edu.sa
N.N.E. El-Sayed1
1Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt 3Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia 4X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800, Malaysia *Corresponding authors: Fax: +966 14675992; Tel: +966 14675898; E-mail: yahia@ksu.edu.sa; ambarakat@ksu.edu.sa
F. Alatibi1
1Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt 3Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia 4X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800, Malaysia *Corresponding authors: Fax: +966 14675992; Tel: +966 14675898; E-mail: yahia@ksu.edu.sa; ambarakat@ksu.edu.sa
A. Barakat1
1Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt 3Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia 4X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800, Malaysia *Corresponding authors: Fax: +966 14675992; Tel: +966 14675898; E-mail: yahia@ksu.edu.sa; ambarakat@ksu.edu.sa
H.A. Ghabbour3
1Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt 3Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia 4X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800, Malaysia *Corresponding authors: Fax: +966 14675992; Tel: +966 14675898; E-mail: yahia@ksu.edu.sa; ambarakat@ksu.edu.sa
H-K. Fun3
1Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt 3Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia 4X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800, Malaysia *Corresponding authors: Fax: +966 14675992; Tel: +966 14675898; E-mail: yahia@ksu.edu.sa; ambarakat@ksu.edu.sa

Corresponding Author(s) : Y.N. Mabkhot1

Asian Journal of Chemistry, Vol. 26 No. 24 (2014)

Abstract

Synthesis of 3-methyl-4-oxo-7-phenyl-4,7-dihydrothieno[2,3-b]pyridine-2-carboxylic acid ethyl ester (3) is described. The structure of the title compound 3 is confirmed by NMR, FT-IR, MS, CHN microanalysis, and X-ray crystallography. Compound 3 is a useful, functionalized pyrido thiophene derivative that can be transformed to novel heteroaromatics of potential pharmacological activities.

Keywords

Thieno[2 3-b]pyridine Enaminones X-Ray.
Mabkhot1, Y., El-Sayed1, N., Alatibi1, F., Barakat1, A., Ghabbour3, H., & Fun3, H.-K. (2014). Synthesis, Characterization and X-Ray Crystal Structure of 3-Methyl-4-oxo-7-phenyl-4,7-dihydrothieno[2,3-b]pyridine-2-carboxyxlic Acid Ethyl Ester. Asian Journal of Chemistry, 26(24), 8596–8598. https://doi.org/10.14233/ajchem.2014.18416
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